2-[1,2,3]Thiadiazol-4-yl-quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[1,2,3]Thiadiazol-4-yl-quinoline
• 英文别名: 4-quinolin-2-ylthiadiazole
• 化学式: C₁₁H₇N₃S
• 分子量: 213.26
• InChiKey: JYJXPNIAKLIXEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 2-PROPENE-1-ONES AS HSP 70 INDUCERS
  申请人：Torrent Pharmaceuticals Ltd

  公开号：EP1748987A2

  公开（公告）日：2007-02-07
• [EN] 2-PROPENE-1-ONES AS HSP 70 INDUCERS<br/>[FR] 2-PROPENE-1-ONES UTILISES COMME INDUCTEURS DE HSP 70
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2005097746A2

  公开（公告）日：2005-10-20

  The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R5, R6, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration.