2-[2-(3,4-Dihydro-2H-quinolin-1-yl)-2-oxo-ethylsulfanyl]-N-phenyl-acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[2-(3,4-Dihydro-2H-quinolin-1-yl)-2-oxo-ethylsulfanyl]-N-phenyl-acetamide
• 英文别名: 2-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]sulfanyl-N-phenylacetamide
• 化学式: C₁₉H₂₀N₂O₂S
• mdl: MFCD01203162
• 分子量: 340.4
• InChiKey: MQEFFKNSZUGYMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF<br/>[FR] RÉGULATEURS DE TYPE PETITE MOLÉCULE DE FUSION MITOCHONDRIALE ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV WASHINGTON

  公开号：WO2018200323A1

  公开（公告）日：2018-11-01

  Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that regulate mitochondrial function are also described.

  描述了包含小分子线粒体融合蛋白激动剂的组合物。这些线粒体融合蛋白调节剂对于治疗与线粒体相关疾病、紊乱或状况有关的疾病或紊乱非常有用，例如与线粒体融合蛋白1（Mfn1）和/或线粒体融合蛋白2（Mfn2）有关的疾病或紊乱，或线粒体功能障碍。还描述了治疗方法、药物配方以及用于识别调节线粒体功能的化合物的筛选方法。
• Small molecule regulators of mitochondrial fusion and methods of use thereof
  申请人：Washington University

  公开号：US10844023B2

  公开（公告）日：2020-11-24

  Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that regulate mitochondrial function are also described.

  本文描述了包含小分子丝裂霉素激动剂的组合物。丝裂素素调节剂可用于治疗与线粒体相关的疾病、紊乱或病症，如与丝裂素素1（Mfn1）和/或丝裂素素2（Mfn2）或线粒体功能障碍相关的疾病或紊乱。还描述了治疗方法、药物制剂和用于鉴定调节线粒体功能的化合物的筛选方法。
• SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF
  申请人：Wahington University

  公开号：US20190169138A1

  公开（公告）日：2019-06-06

  Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that regulate mitochondrial function are also described.
• [EN] MITOFUSIN ACTIVATORS AND USES THEREOF<br/>[FR] ACTIVATEURS DE MITOFUSINES ET LEURS UTILISATIONS
  申请人：ALBERT EINSTEIN COLLEGE MEDICINE INC

  公开号：WO2019079243A1

  公开（公告）日：2019-04-25

  Activators of mitofusins and their uses in treatment of diseases and disorders are disclosed.