(4R,9S,10S,12R,E)-15-(benzyloxy)-10,12-bis((tert-butyldimethylsilyl)oxy)-4-((triethylsilyl)oxy)-6,9-dimethylpentadec-6-en-8-one | 1309595-83-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4R,9S,10S,12R,E)-15-(benzyloxy)-10,12-bis((tert-butyldimethylsilyl)oxy)-4-((triethylsilyl)oxy)-6,9-dimethylpentadec-6-en-8-one
• 英文别名: (E,4R,9S,10S,12R)-10,12-bis[[tert-butyl(dimethyl)silyl]oxy]-6,9-dimethyl-15-phenylmethoxy-4-triethylsilyloxypentadec-6-en-8-one
• CAS: 1309595-83-2
• 化学式: C₄₂H₈₀O₅Si₃
• 分子量: 749.351
• InChiKey: KGDNFZSWAOJKAF-ZNFLKEEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.89
• 重原子数：
  50
• 可旋转键数：
  26
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (4R,9S,10S,12R,E)-15-(benzyloxy)-10,12-bis((tert-butyldimethylsilyl)oxy)-4-((triethylsilyl)oxy)-6,9-dimethylpentadec-6-en-8-one 在 咪唑 、 氢气 、 碘 、 L-Selectride 、 N,N-二异丙基乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 、 1,2-二氯乙烷 为溶剂， -78.0~50.0 ℃ 、101.33 kPa 条件下， 反应 10.75h， 生成 (5R,9R,10R,11S,13R)-11-((tert-butyldimethylsilyl)oxy)-3,3-diethyl-13-(3-iodopropyl)-9-(methoxymethoxy)-7,10,15,15,16,16-hexamethyl-5-propyl-4,14-dioxa-3,15-disilaheptadec-7-ene
  参考文献：
  名称：

  Highly Demanding Cross-Metathesis in the Synthesis of the C16–C30 Fragment of Dolabelide C

  摘要：

  A highly demanding cross-metathesis (CM) reaction for the formation of the C24-C25 trisubstituted olefin of dolabelide C has been optimized. A difference in reactivity between the E and Z enone isomers in this reaction was uncovered, and the selection of the Z isomer of the starting enone was critical for the success of the cross-metathesis. Application to the synthesis of the C16-C30 fragment of dolabelide C is reported.

  DOI：

  10.1021/jo200466t
• 作为产物：
  描述：

  (R)-1,2-环氧基戊烷 在 copper(l) iodide 、 Hoveyda-Grubbs catalyst second generation 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 75.5h， 生成 (4R,9S,10S,12R,E)-15-(benzyloxy)-10,12-bis((tert-butyldimethylsilyl)oxy)-4-((triethylsilyl)oxy)-6,9-dimethylpentadec-6-en-8-one
  参考文献：
  名称：

  Highly Demanding Cross-Metathesis in the Synthesis of the C16–C30 Fragment of Dolabelide C

  摘要：

  A highly demanding cross-metathesis (CM) reaction for the formation of the C24-C25 trisubstituted olefin of dolabelide C has been optimized. A difference in reactivity between the E and Z enone isomers in this reaction was uncovered, and the selection of the Z isomer of the starting enone was critical for the success of the cross-metathesis. Application to the synthesis of the C16-C30 fragment of dolabelide C is reported.

  DOI：

  10.1021/jo200466t