3H-Cyclopenta[c]quinoline-4-carboxylic acid, 3a,4,5,9b-tetrahydro-8-chloro-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3H-Cyclopenta[c]quinoline-4-carboxylic acid, 3a,4,5,9b-tetrahydro-8-chloro-
• 英文别名: 8-chloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid
• 化学式: C₁₃H₁₂ClNO₂
• 分子量: 249.69
• InChiKey: XQVYWCCDLAHPNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives
  申请人：GRUENENTHAL GmbH

  公开号：US20030087926A1

  公开（公告）日：2003-05-08

  A substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivative of formula I 1 and salts thereof with pharmaceutically acceptable acids. Also disclosed are methods for making the derivative, and pharmaceutical compositions comprising the derivative. Methods for treating pain, migraine, and various other diseases using the pharmaceutical composition are also disclosed.

  一种公式I的1,2,3,4-四氢喹啉-2-羧酸衍生物及其与药用酸盐。还公开了制备该衍生物的方法，以及包含该衍生物的药物组合物。还公开了使用该药物组合物治疗疼痛、偏头痛和其他各种疾病的方法。
• Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
  申请人：Gruenenthal GmbH

  公开号：US20040224969A1

  公开（公告）日：2004-11-11

  Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds, processes for their preparation, drugs containing these compounds and their use in treatment methods and for the preparation of drugs for specific indications, especially for the treatment of pain.

  1,2,3,4-四氢喹啉-2-羧酸替代盐的化合物，其制备方法，含有这些化合物的药物以及它们在治疗方法和制备特定适应症的药物中的应用，尤其是用于治疗疼痛。
• PDZ DOMAIN MODULATORS
  申请人：Gether Ulrik

  公开号：US20100249165A1

  公开（公告）日：2010-09-30

  This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.

  本发明涉及用作PDZ结构域调节剂的化合物，特别是用于PICK1的PDZ结构域。在其他方面，本发明涉及这些化合物在治疗方法中的应用以及药物组成物。
• SUBSTITUIERTE 1,2,3,4-TETRAHYDROCHINOLIN-2-CARBONSÄUREDERIVATE
  申请人：Grünenthal GmbH

  公开号：EP1254118B1

  公开（公告）日：2005-11-09
• PAPD5 INHIBITORS AND METHODS OF USE THEREOF
  申请人：Children`s Medical Center Corporation

  公开号：US20210177827A1

  公开（公告）日：2021-06-17

  The disclosure relates to compounds that are, e.g., PAP Associated Domain Containing 5 (PAPD5) inhibitors and methods of use thereof.