5-(3-Bromo-phenyl)-2,2-dimethyl-2,3,5,6-tetrahydro-1H-benzo[a]phenanthridin-4-one | 22949-39-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(3-Bromo-phenyl)-2,2-dimethyl-2,3,5,6-tetrahydro-1H-benzo[a]phenanthridin-4-one
• 英文别名: Benzo[a]phenanthridin-4(3H)-one, 1,2,5,6-tetrahydro-2,2-dimethyl-5-(3-bromophenyl)-；5-(3-bromophenyl)-2,2-dimethyl-1,3,5,6-tetrahydrobenzo[a]phenanthridin-4-one
• CAS: 22949-39-9
• 化学式: C₂₅H₂₂BrNO
• 分子量: 432.36
• InChiKey: DSQADTIMDSAVQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C
  申请人：Cerione Kristin Wilson

  公开号：US20130252983A1

  公开（公告）日：2013-09-26

  A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.
• [EN] INHIBITION OF GLUTAMINASE C<br/>[FR] INHIBITION DE LA GLUTAMINASE C
  申请人：UNIV CORNELL

  公开号：WO2010111504A2

  公开（公告）日：2010-09-30

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
• [EN] ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C<br/>[FR] ACTIVATION DU SITE DE PHOSPHORYLATION SUR LA GLUTAMINASE C
  申请人：UNIV CORNELL

  公开号：WO2012034123A1

  公开（公告）日：2012-03-15

  A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.