2-[(2-Hydroxyethyl)(methyl)amino]cyclohexan-1-ol | 854815-53-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(2-Hydroxyethyl)(methyl)amino]cyclohexan-1-ol
• 英文别名: 2-[2-hydroxyethyl(methyl)amino]cyclohexan-1-ol
• CAS: 854815-53-5
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: KPUSMNAYGYVMRO-UHFFFAOYSA-N

物化性质

• 沸点：
  168 °C(Press: 15 Torr)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[(2-Hydroxyethyl)(methyl)amino]cyclohexan-1-ol 、 六甲基二硅氮烷 反应 70.0h， 以86%的产率得到Methyl-(2-trimethylsilanyloxy-cyclohexyl)-(2-trimethylsilanyloxy-ethyl)-amine
  参考文献：
  名称：

  The transannular interaction germanium–nitrogen in germocanes: The influence of substituents

  摘要：

  The reaction of RN(CH2CH2OH)(CHRCRROH)-C-1-R-2-O-3 (1-8) with a stoichiometric amount of tetrachloro(bromo)germane leads to the corresponding RN(CH2CH2O)((CHRCRRO)-C-1-R-2-O-3)GeHal(2) (9-21). Difluorenylgermocane 22 was prepared by treatment of diethoxydifluorenylgermane with N-methyldiethanolamine. Different dialkanolamines were found to be successive precursors of dimethylgermocanes, RN(CH2CH2O)((CHRCRRO)-C-1-R-2-O-3)GeMe2 (23-26). The chemical properties of simple and easy to access germocanes RN(CH2CH2O)(2)GeX2 [X=OH, Br (28), Cl (29)] were studied and the difluoro (27), haloalkoxy (30-32), and dialkoxy (33, 34) derivatives were prepared. The structures of the compounds 16, 20-22, and 26 were confirmed by X-ray diffraction and the structural features in solution of 23 and 26 were studied by NMR spectroscopy (NOES). The relationship between the nature of substituents at different positions of the germocane skeleton and the strength of the intramolecular Ge <- N bond is discussed. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2006.08.011
• 作为产物：
  描述：

  N-甲基-2-羟基乙胺 、 氧化环己烯 反应 48.0h， 以88%的产率得到2-[(2-Hydroxyethyl)(methyl)amino]cyclohexan-1-ol
  参考文献：
  名称：

  二链烷醇胺配体的钛配合物：合成与结构

  摘要：

  标题化合物的合成，即。[RN(CH 2 CH 2 O)-(CHR 1 CR 2 R 3 O)]Ti(OiPr) 2 (13-15) 和[RN(CH 2 CH 2 O)-(CHR 1 CR 2 R 3 O) ] 2 Ti (18-28)，通过一或两当量的相应二烷醇胺 RN(CH 2 CH 2 OH)(CHR 1 CR 2 R 3 OH) (1-12) 与 Ti(OiPr) 4 的反应是报道。[RN(CH 2 CH 2 O)(CHR 1 CR 2 R 3 O)] 2 Ti的其他途径，例如Ti(CH 2 Ph) 4 与二烷醇胺的反应以及TiCl 4 (THF) 2 与还测试了二烷醇胺/Et 3 N。二聚钛烷16，[PhCH 2 N(CH 2 CH 2 O) 2 Ti-(OMe) 2 ] 2 ，由一当量二烷醇胺3与CpTi(OMe) 3 ，PhCH 2 N(CH 2 CH)反应获得2 O) 2 -Ti(OMenth)

  DOI：

  10.1002/ejic.200501154

文献信息

• Stabilized germylenes based on dialkanolamines: Synthesis, structure, chemical properties
  作者：Mengmeng Huang、Marina M. Kireenko、Kirill V. Zaitsev、Yuri F. Oprunenko、Andrei V. Churakov、Judith A.K. Howard、Maxim V. Zabalov、Elmira Kh. Lermontova、Jörg Sundermeyer、Thomas Linder、Sergey S. Karlov、Galina S. Zaitseva

  DOI：10.1016/j.jorganchem.2012.01.018

  日期：2012.6

  dimeric in the solid state due to the formation of intermolecular Ge–O bonds, the complex 10 is monomeric, all compounds possess a transannular Ge–N bond. The reactivity of the germylenes synthesized was investigated in reactions of oxidative insertion (with halogenation reagents, MeI, disulfides), [1 + 4]-cycloaddition, oxidation and in reactions with water and acetic anhydride. Some reactions were investigated

  一系列新型的低的价锗化合物RN（CHR 2 CR 1 - [R 3 O）（CHR 4 CHR 5 O）的Ge 1 - 13（- [R  = Me中，pH值，BN; [R 1，- [R 2，- [R 3，- [R 4，通过Ge [N（SiMe 3）2 ]之间的反应获得R 5  ＝ H，Me，Ph，（CH 2）3，（CH 2）4，CH 2（C 6 H 4））。2和各种二链烷醇胺。通过元素分析，所有新化合物进行了表征1个H和13 C NMR光谱和在一些情况下通过X射线衍射分析（1，3，8，10）。化合物1，3，8是在固体状态二聚体由于分子间的Ge-O键的形成，该复合物10由于是单体，所有化合物均具有跨环的Ge–N键。在氧化插入（与卤化试剂，MeI，二硫化物），[1 + 4]-环加成，氧化以及与水和乙酸酐的反应中，研究了合成的亚甲基苯的反应性。通过DFT计算研究了一些反应。
• [EN] ABSORBENT SOLUTION MADE FROM TERTIARY DIAMINES BELONGING TO THE HINDERED AMINOETHYL MORPHOLINE FAMILY AND METHOD FOR ELIMINATING ACID COMPOUNDS FROM A GASEOUS EFFLUENT<br/>[FR] SOLUTION ABSORBANTE A BASE DE DIAMINES TERTIAIRES APPARTENANT A LA FAMILLE DES AMINOETHYLMORPHOLINES ENCOMBREES ET PROCEDE D'ÉLIMINATION DE COMPOSES ACIDES D'UN EFFLUENT GAZEUX
  申请人：IFP ENERGIES NOUVELLES

  公开号：WO2014001664A1

  公开（公告）日：2014-01-03

  Solution absorbante (4), et procédé mettant en oeuvre cette solution pour éliminer des composés acides contenus dans un effluent gazeux (1), comportant de l'eau et au moins un composé azoté choisi dans le groupe des 4-(aminoéthyl)-morpholines tertiaires encombrées répondant à la formule générale (I) suivante; avec R1, R2, R3 et R4 choisis indépendamment parmi un atome d'hydrogène et un radical alkyle comportant 1 à 4 atomes de carbone, et où soit R5 est un radical alkyle comportant 1 à 5 atomes de carbone et R6 est un radical alkyle comportant 3 à 5 atomes de carbone avec l'atome de carbone de R6 lié à l'atome d'azote étant tertiaire ou quaternaire, soit R5 et R6 sont des radicaux alkyles, reliés entre eux par une liaison covalente, lesdits radicaux R5 et R6 comportant 1 à 5 atomes de carbone et étant choisis de manière à former un cycle constitué de 5, 6 ou 7 atomes.
• The transannular interaction germanium–nitrogen in germocanes: The influence of substituents
  作者：Elmira Kh. Lermontova、Anastasia A. Selina、Sergey S. Karlov、Andrei V. Churakov、Judith A.K. Howard、Yuri F. Oprunenko、Mikhail Yu. Antipin、Jörg Sundermeyer、Galina S. Zaitseva

  DOI：10.1016/j.jorganchem.2006.08.011

  日期：2006.12

  The reaction of RN(CH2CH2OH)(CHRCRROH)-C-1-R-2-O-3 (1-8) with a stoichiometric amount of tetrachloro(bromo)germane leads to the corresponding RN(CH2CH2O)((CHRCRRO)-C-1-R-2-O-3)GeHal(2) (9-21). Difluorenylgermocane 22 was prepared by treatment of diethoxydifluorenylgermane with N-methyldiethanolamine. Different dialkanolamines were found to be successive precursors of dimethylgermocanes, RN(CH2CH2O)((CHRCRRO)-C-1-R-2-O-3)GeMe2 (23-26). The chemical properties of simple and easy to access germocanes RN(CH2CH2O)(2)GeX2 [X=OH, Br (28), Cl (29)] were studied and the difluoro (27), haloalkoxy (30-32), and dialkoxy (33, 34) derivatives were prepared. The structures of the compounds 16, 20-22, and 26 were confirmed by X-ray diffraction and the structural features in solution of 23 and 26 were studied by NMR spectroscopy (NOES). The relationship between the nature of substituents at different positions of the germocane skeleton and the strength of the intramolecular Ge <- N bond is discussed. (c) 2006 Elsevier B.V. All rights reserved.
• Titanium Complexes of Dialkanolamine Ligands: Synthesis and Structure
  作者：Kirill V. Zaitsev、Sergey S. Karlov、Anastasia A. Selina、Yu. F. Oprunenko、Andrei V. Churakov、Bernhard Neumüller、Judith A. K. Howard、Galina S. Zaitseva

  DOI：10.1002/ejic.200501154

  日期：2006.5

  with dialkanolamine and the reaction of TiCl 4 (THF) 2 with dialkanolamine/Et 3 N were also tested. Dimeric titanocane 16, [PhCH 2 N(CH 2 CH 2 O) 2 Ti-(OMe) 2 ] 2 , was obtained from the reaction of one equivalent of dialkanolamine 3 with CpTi(OMe) 3 , PhCH 2 N(CH 2 CH 2 O) 2 -Ti(OMenth) 2 (17) was prepared from the transalkoxylation reaction of 15 with two equivalents of menthol. The composition and structures

  标题化合物的合成，即。[RN(CH 2 CH 2 O)-(CHR 1 CR 2 R 3 O)]Ti(OiPr) 2 (13-15) 和[RN(CH 2 CH 2 O)-(CHR 1 CR 2 R 3 O) ] 2 Ti (18-28)，通过一或两当量的相应二烷醇胺 RN(CH 2 CH 2 OH)(CHR 1 CR 2 R 3 OH) (1-12) 与 Ti(OiPr) 4 的反应是报道。[RN(CH 2 CH 2 O)(CHR 1 CR 2 R 3 O)] 2 Ti的其他途径，例如Ti(CH 2 Ph) 4 与二烷醇胺的反应以及TiCl 4 (THF) 2 与还测试了二烷醇胺/Et 3 N。二聚钛烷16，[PhCH 2 N(CH 2 CH 2 O) 2 Ti-(OMe) 2 ] 2 ，由一当量二烷醇胺3与CpTi(OMe) 3 ，PhCH 2 N(CH 2 CH)反应获得2 O) 2 -Ti(OMenth)