7-[2-Pyridinyl(2-pyridinylamino)methyl]-8-quinolinol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-[2-Pyridinyl(2-pyridinylamino)methyl]-8-quinolinol
• 英文别名: 7-[pyridin-2-yl-(pyridin-2-ylamino)methyl]quinolin-8-ol
• 化学式: C₂₀H₁₆N₄O
• 分子量: 328.4
• InChiKey: ODYWXTWUNZPEGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  70.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PROLYLHYDROXYLASE/ATF4 INHIBITORS FOR TREATING NEURAL CELL INJURY
  申请人：Cornell University

  公开号：EP3079697B1

  公开（公告）日：2021-02-03
• PROLYLHYDROXYLASE/ATF4 INHIBITORS AND METHODS OF USE FOR TREATING NEURAL CELL INJURY OR DEATH AND CONDITIONS RESULTING THEREFROM
  申请人：CORNELL UNIVERSITY

  公开号：US20200360366A1

  公开（公告）日：2020-11-19

  Methods for treating a patient suffering from neural cell injury, the method comprising administering to the patient an effective amount of a HIE prolyl-4-hydroxylase inhibiting compound having the following general formula (1) wherein R 1 is a cyclic group containing at least three and up to seven carbon atoms and optionally containing one or more heteroatoms selected from O, N, and S, and optionally attached to the shown carbon atom by a linking group; R 2 is independently selected from said cyclic groups of R 1 and a cyclic hydrocarbon groups R 5 containing up to twenty carbon atoms; R 3 is selected from hydrogen atom and hydrocarbon groups containing up to six carbon atoms; R 6 and R 7 are independently selected from hydrogen atom, hydrocarbon groups containing up to three carbon atoms, halogen atom, and polar groups, as well as methylene-linked versions thereof; and t is 0 or 1.
• [EN] PROLYLHYDROXYLASE/ATF4 INHIBITORS FOR TREATING NEURAL CELL INJURY<br/>[FR] INHIBITEURS DE LA PROLYLHYDROXYLASE/ATF4 POUR LE TRAITEMENT DES LÉSIONS CELLULAIRES NEURONALES
  申请人：UNIV CORNELL

  公开号：WO2015089416A1

  公开（公告）日：2015-06-18

  Methods for treating a patient suffering from neural cell injury, the method comprising administering to the patient an effective amount of a HIF prolyl-4-hydroxylase inhibiting compound having the following general formula (1) wherein R1 is a cyclic group containing at least three and up to seven carbon atoms and optionally containing one or more heteroatoms selected from O, N, and S, and optionally attached to the shown carbon atom by a linking group; R2 is independently selected from said cyclic groups of R1 and acyclic hydrocarbon groups R5 containing up to twenty carbon atoms; R3 is selected from hydrogen atom and hydrocarbon groups containing up to six carbon atoms; R6 and R7 are independently selected from hydrogen atom, hydrocarbon groups containing up to three carbon atoms, halogen atom, and polar groups, as well as methylene-linked versions thereof; and t is 0 or 1.