8-Methoxy-quinoline-5-sulfonic acid (2,5-dimethoxy-phenyl)-amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Methoxy-quinoline-5-sulfonic acid (2,5-dimethoxy-phenyl)-amide
• 英文别名: N-(2,5-dimethoxyphenyl)-8-methoxyquinoline-5-sulfonamide
• 化学式: C₁₈H₁₈N₂O₅S
• 分子量: 374.4
• InChiKey: BVXQAEGXFAFRBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  95.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS<br/>[FR] INHIBITEURS DE KINASES CAPABLES DE RENFORCER LA SENSIBILITÉ D'AGENTS PATHOGÈNES BACTÉRIENS AUX ANTIBIOTIQUES DE LA FAMILLE DES B-LACTAMINES
  申请人：SEATTLE CHILDREN S RES INST

  公开号：WO2013066469A2

  公开（公告）日：2013-05-10

  Staphylococcus aureus are gram-positive bacteria that are currently the leading cause of invasive infections in humans. While antibiotic therapy is currently used to treat S. aureus infections, the emergence of antibiotic resistant strains such as those resistant to methicillan are rapidly exhausting treatment options. Disclosed herein are methods and compositions for increasing the sensitivity of bacterial pathogens to β-lactam antibiotics. Also disclosed herein are genes involved in modulating antibiotic resistance which serve as novel targets for treatments aimed at inhibiting antibiotic resistant bacterial pathogens. Also disclosed herein are kinase inhibitors which demonstrate superior activity in sensitizing bacterial pathogens to β-lactam antibiotics.