4-chloro-5-nitro-2-phenylthiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-chloro-5-nitro-2-phenylthiazole
• 英文别名: Thiazole, 4-chloro-5-nitro-2-phenyl-；4-chloro-5-nitro-2-phenyl-1,3-thiazole
• 化学式: C₉H₅ClN₂O₂S
• 分子量: 240.67
• InChiKey: UJYOBZOYYFXFLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-5-nitro-2-phenylthiazole 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以56%的产率得到4-azido-5-nitro-2-phenylthiazole
  参考文献：
  名称：

  Neighbouring group effects on rates of thermolysis of 4-azidothiazoles

  摘要：

  Rate measurements for thermolysis of 4-azidothiazoles in p-xylene solution have identified neighbouring group effects from nitro (19-fold rate increase), phenyliminomethyl (16), formyl (4.5) and acetyl (2.2) substituents in the 5-position. These effects are very similar in magnitude to those measured for 3-azidothiophenes, whereas in azidobenzenes the rate increases are much larger, 5-Substituents in 4-azidothiazole which are capable of conjugative donation (phenyl, ethyl propenoate) also increased the reaction rate. The reactions involving neighbouring group participation led to cyclized products from the 4-azidothiazoles though not all of these products were stable under the thermolysis conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00638-8
• 作为产物：
  描述：

  4-chloro-2-phenylthiazole 在 硝酸 、 乙酸酐 作用下， 以57%的产率得到4-chloro-5-nitro-2-phenylthiazole
  参考文献：
  名称：

  Neighbouring group effects on rates of thermolysis of 4-azidothiazoles

  摘要：

  Rate measurements for thermolysis of 4-azidothiazoles in p-xylene solution have identified neighbouring group effects from nitro (19-fold rate increase), phenyliminomethyl (16), formyl (4.5) and acetyl (2.2) substituents in the 5-position. These effects are very similar in magnitude to those measured for 3-azidothiophenes, whereas in azidobenzenes the rate increases are much larger, 5-Substituents in 4-azidothiazole which are capable of conjugative donation (phenyl, ethyl propenoate) also increased the reaction rate. The reactions involving neighbouring group participation led to cyclized products from the 4-azidothiazoles though not all of these products were stable under the thermolysis conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00638-8

文献信息

• Neighbouring group effects on rates of thermolysis of 4-azidothiazoles
  作者：Erik Ceulemans、Karin Vercauteren、Leonard K. Dyall、Dirk Buelens、Wim Dehaen

  DOI：10.1016/s0040-4020(97)00638-8

  日期：1997.7

  Rate measurements for thermolysis of 4-azidothiazoles in p-xylene solution have identified neighbouring group effects from nitro (19-fold rate increase), phenyliminomethyl (16), formyl (4.5) and acetyl (2.2) substituents in the 5-position. These effects are very similar in magnitude to those measured for 3-azidothiophenes, whereas in azidobenzenes the rate increases are much larger, 5-Substituents in 4-azidothiazole which are capable of conjugative donation (phenyl, ethyl propenoate) also increased the reaction rate. The reactions involving neighbouring group participation led to cyclized products from the 4-azidothiazoles though not all of these products were stable under the thermolysis conditions. (C) 1997 Elsevier Science Ltd.

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