3-Benzyl-1-(3-dimethylamino-propyl)-1-(7,8-dimethyl-2-oxo-1,2-dihydro-quinolin-3-ylmethyl)-urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-Benzyl-1-(3-dimethylamino-propyl)-1-(7,8-dimethyl-2-oxo-1,2-dihydro-quinolin-3-ylmethyl)-urea
• 英文别名: 3-benzyl-1-[3-(dimethylamino)propyl]-1-[(7,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]urea
• 化学式: C₂₅H₃₂N₄O₂
• 分子量: 420.5
• InChiKey: MTTWXLYEPWOSKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Inhibitors of N-linked glycosylation and methods using same
  申请人：YALE UNIVERSITY

  公开号：US11219625B2

  公开（公告）日：2022-01-11

  The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.

  本发明包括用于预防或治疗有需要的受试者与N-连接糖基化相关的疾病的新型化合物和方法。这些方法包括向受试者施用有效量的至少一种本发明化合物。
• Inhibitors of N-Linked Glycosylation and Methods Using Same
  申请人：YALE UNIVERSITY

  公开号：US20190000858A1

  公开（公告）日：2019-01-03

  The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.
• [EN] INHIBITORS OF N-LINKED GLYCOSYLATION AND METHODS USING SAME<br/>[FR] INHIBITEURS DE GLYCOSYLATION À LIAISON EN N ET PROCÉDÉS LES UTILISANT
  申请人：UNIV YALE

  公开号：WO2017019540A2

  公开（公告）日：2017-02-02

  The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound of the invention.