2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl thiophene-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl thiophene-2-carboxylate
• 英文别名: (2,2,4-trimethyl-1H-quinolin-6-yl) thiophene-2-carboxylate
• 化学式: C₁₇H₁₇NO₂S
• mdl: MFCD02221846
• 分子量: 299.4
• InChiKey: QUZPIEFRIXWLQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Chemical entities that kill senescent cells for use in treating age-related disease
  申请人：Unity Biotechnology, Inc.

  公开号：US10195213B2

  公开（公告）日：2019-02-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.

  本文公开的化合物可有效治疗与衰老有关的各种疾病状态。所公开的化合物可用于消除衰老细胞以治疗疾病。化合物的给药方式包括单次给药和循环给药。
• Molecules, compositions and methods for modulation of SIRT6
  申请人：SirTLab Corporation

  公开号：US10857170B1

  公开（公告）日：2020-12-08

  A SIRT6 activating molecule as shown in Tables 1-3 or a compound according to a pharmacophore as described herein.

  如表 1-3 所示的 SIRT6 激活分子或符合本文所述药理作用的化合物。
• COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION
  申请人：Carlson Heather A.

  公开号：US20110105477A1

  公开（公告）日：2011-05-05

  The present invention relates to HIV protease, and methods for inhibiting the function of HIV protease. In particular, present invention provides compounds that inhibit or block the biological activity of HIVp, thereby causing the replication of the HIV virus to be inhibited or to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS. The compounds and formulations also find use in diagnostic and research settings.
• COMPOUNDS AND THERAPEUTIC USES
  申请人：Unity Biotechnology, Inc.

  公开号：US20170281649A1

  公开（公告）日：2017-10-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.