2-Methyl-2-methylaminopropiophenon | 1011-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-2-methylaminopropiophenon
• 英文别名: 2-Methyl-2-(methylamino)-1-phenylpropan-1-one
• CAS: 1011-07-0
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: JLVGGPQTLAPRPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methyl-2-methylaminopropiophenon 在 盐酸 作用下， 以 乙醚 、 乙酸乙酯 为溶剂， 反应 2.0h， 以21%的产率得到2-methyl-2-methylamino-1-phenyl-propan-1-one; hydrochloride
  参考文献：
  名称：

  Investigation of the Optical Isomers of Methcathinone, and Two Achiral Analogs, at Monoamine Transporters and in Intracranial Self-Stimulation Studies in Rats

  摘要：

  Methcathinone (MCAT; 1), the progenitor of numerous and widely abused "synthetic cathinone" central stimulants, exists as a pair of optical isomers. Although S(-)MCAT is several-fold more potent than R(+)MCAT in rodent locomotor stimulation and in stimulus generalization studies in rat drug discrimination assays, the individual optical isomers of MCAT have never been directly compared for their actions at monoamine transporters that seem to underlie their actions and have never been examined for their relative abuse potential. Here, we found that the isomers of MCAT are nearly equieffective at dopamine and norepinephrine transporters (DAT and NET, respectively) as transporter substrates (i.e., as releasing agents) and are >= 63-fold less potent at the serotonin transporter (SERT). In intracranial self-stimulation (ICSS) studies to evaluate abuse-related drug effects in rats, S(-)MCAT was approximately twice as potent as its R-enantiomer. Achiral analogs, alpha-methyl MCAT (3) and alpha-des-methyl MCAT (4), also were DAT/NET substrates and also produced abuse-related ICSS effects, indicating that they retain abuse potential and that they might be useful for the further study of the stereochemistry of synthetic cathinone analogs with chiral beta- (or other) substituents.

  DOI：

  10.1021/acschemneuro.9b00617
• 作为产物：
  描述：

  2-methoxy-3,3-dimethyl-2-phenyl-oxirane 、 甲胺 以 苯 为溶剂， 生成 2-Methyl-2-methylaminopropiophenon
  参考文献：
  名称：

  Schulz,H., Pharmazie, 1967, vol. 22, p. 19 - 22

  摘要：

  DOI：

文献信息

• 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING
  申请人：DYBALLA Katrin Marie

  公开号：US20170298013A1

  公开（公告）日：2017-10-19

  Novel 2,2′-diamino biaryls of formula (I), (II) and (III), wherein R1-R10, R1′-R10′, X1-X3 and X1-X3′ are defined in claim 1. The invention also relates to an electrochemical method for the production thereof.

  本发明涉及化学式（I），（II）和（III）的新型2,2'-二氨基联苯，其中R1-R10，R1'-R10'，X1-X3和X1-X3'在权利要求书1中定义。本发明还涉及一种电化学制备它们的方法。
• 2,2' -DIAMINOBIARYLS HAVING A PHTHALOYL GROUP OR SUCCINOYL GROUP
  申请人：DYBALLA Katrin Marie

  公开号：US20170305846A1

  公开（公告）日：2017-10-26

  Novel 2,2′-diaminobiaryls having two secondary amines and an electrochemical process for preparation thereof.

  小说2,2'-二氨基二芳基化合物具有两个次级胺基和一种电化学制备方法。
• 2,2' -DIAMINOBIARYLS HAVING ONE PRIMARY AND ONE SECONDARY AMINE
  申请人：DYBALLA Katrin Marie

  公开号：US20170291871A1

  公开（公告）日：2017-10-12

  Novel 2,2′-diaminobiaryls having one primary and one secondary amine and an electrochemical process for preparation thereof.

  小说2,2'-二氨基联苯具有一个主要胺基和一个次要胺基和一种电化学制备方法。
• 2,2′-diaminobiaryls having two secondary amines
  申请人：EVONIK DEGUSSA GMBH

  公开号：US10196747B2

  公开（公告）日：2019-02-05

  Novel 2,2′-diaminobiaryls having two secondary amines and an electrochemical process for preparation thereof.

  小说2,2'-二氨基联苯具有两个次要胺基和其制备的电化学过程。
• Über die Synthese einiger dem Ephedrin verwandter Substanzen
  作者：C. Mannich、H. Budde

  DOI：10.1002/ardp.19332710104

  日期：——