3,5,7-trichloro-2-phenyl-2H-indazole | 88279-09-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,5,7-trichloro-2-phenyl-2H-indazole
• 英文别名: 3,5,7-Trichlor-2-phenyl-2H-indazol；3,5,7-Trichloro-2-phenyl-2H-indazole；3,5,7-trichloro-2-phenylindazole
• CAS: 88279-09-8
• 化学式: C₁₃H₇Cl₃N₂
• 分子量: 297.571
• InChiKey: LEWBNDXDTDFRLA-UHFFFAOYSA-N

物化性质

• 熔点：
  208-210 °C
• 沸点：
  276.6±40.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,5,7-trichloro-2-phenyl-2H-indazole 、 溶剂黄146 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3,5-dichloro-2-phenylazo-benzoic acid
  参考文献：
  名称：

  Kenner, Journal of the Chemical Society, 1914, vol. 105, p. 2736

  摘要：

  DOI：
• 作为产物：
  描述：

  2-azido-N-phenylbenzamide 在 五氯化磷 作用下， 反应 16.0h， 以65%的产率得到3,5,7-trichloro-2-phenyl-2H-indazole
  参考文献：
  名称：

  Ardakani, Manouchehr Azadi; Smalley, Robert K.; Smith, Richard H., Journal of the Chemical Society. Perkin transactions I, 1983, # 10, p. 2501 - 2506

  摘要：

  DOI：

文献信息

• Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
  作者：Changjun Zhang、Tingting Wei、Zhichen Yu、Yuxin Ding、Weike Su、Yuanyuan Xie

  DOI：10.1039/d2ra07398f

  日期：——

  An unprecedented metal-free regioselective halogenation of 2H-indazoles is reported, and not only realizes the highly selective synthesis of mono-halogenated products, but also complete poly-halogenations.

  该研究报道了一种前所未有的 2H-indazoles 无金属区域选择性卤化反应，不仅实现了单卤化产物的高选择性合成，还实现了完全的多卤化反应。
• Age-Related Changes in Protein Oxidation and Proteolysis in Mammalian Cells
  作者：T. Grune、R. Shringarpure、N. Sitte、K. Davies

  DOI：10.1093/gerona/56.11.b459

  日期：2001.11.1

  Reactive oxygen species generated as by-products of oxidative metabolism, or from environmental sources, frequently damage cellular macromolecules. Proteins are recognized as major targets of oxidative modification, and the accumulation of oxidized proteins is a characteristic feature of aging cells. An increase in the amount of oxidized proteins has been reported in many experimental aging models, as measured by the level of intracellular protein carbonyls or dityrosine, or by the accumulation of protein-containing pigments such as lipofuscin and ceroid bodies. In younger individuals, moderately oxidized soluble cell proteins appear to be selectively recognized and rapidly degraded by the proteasome. An age-related accumulation of oxidized proteins could, therefore, be a result of declining activity of the proteasome. Previous research to investigate the notion of an age-related decline in the content and/or activity of the proteasome has generated contradictory results. The latest evidence, including our own recent findings, indicates that proteasome activity does, indeed, decline during aging as the enzyme complex is progressively inhibited by oxidized and cross-linked protein aggregates. We propose that cellular aging involves both an increase in (mitochondrial) oxidant production and a progressive decline in proteasome activity. Eventually so much proteasome is inactivated that oxidized proteins begin to accumulate rapidly and contribute to cellular dysfunction and senescence.
• ARDAKANI, MANOUCHEHR, AZADI;SMALLEY, R. K.;SMITH, R. H., J. CHEM. SOC. PERKIN TRANS., 1983, N 10, 2501-2506
  作者：ARDAKANI, MANOUCHEHR, AZADI、SMALLEY, R. K.、SMITH, R. H.

  DOI：——

  日期：——