8-Methyl-2-morpholin-4-ylquinoline-3-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Methyl-2-morpholin-4-ylquinoline-3-carbaldehyde
• 化学式: C₁₅H₁₆N₂O₂
• 分子量: 256.3
• InChiKey: HHCANZKGWPOQQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOSES DERIVES D'IRIDOIDES PROTEGES OU NON, COMPOSITION LES COMPRENANT, UTILISATION COMME COLORANT DES FIBRES KERATINIQUES ET DISPOSITIFS
  申请人：L'Oréal

  公开号：EP2978749A1

  公开（公告）日：2016-02-03
• PROCEDE DE COLORATION UTILISANT UN PRECURSEUR DE COLORATION CAPILLAIRE ISSU D'IRIDOIDE, COMPOSITION, PRECURSEUR ET DISPOSITIF LE COMPRENANT
  申请人：L'OREAL

  公开号：EP2978767B1

  公开（公告）日：2018-10-03
• [EN] DYE COMPOSITION COMPRISING A GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICES THEREFOR<br/>[FR] COMPOSITION DE COLORANT COMPRENANT UN COMPOSÉ IRIDOÏDE GLYCOSYLIQUE ET UN ALDÉHYDE PARTICULIER OU UNE IMINE PARTICULIÈRE, PROCÉDÉ DE COLORATION ET DISPOSITIFS S'Y RAPPORTANT
  申请人：OREAL

  公开号：WO2013045704A2

  公开（公告）日：2013-04-04

  The present invention relates to a composition for dyeing human keratin fibres, comprising, in a cosmetically acceptable medium: * a compound of the iridoid family of formula (I) below, or a plant extract comprising the same: in which R1: hydrogen, methyl, hydroxymethyl, aldehyde; -CO2R4 in which R4: hydrogen, C1-C2 alkyl; sugar; R2: a hydrogen atom, a hydroxyl radical, sugar radical; R3: hydrogen, hydroxyl, alkyloxy; R: sugar radical (aldose or derivative); integer ranging from 1 to 5; the compound(s) of formula (I) having optionally undergone a preliminary step consisting in replacing the radical R with a hydrogen atom, performed using an enzyme; ** at least one aldehyde or imine compound of formulae (i) and (ii), and also oxidized oligo- or polysaccharide comprising at least one aldehyde or imine function: with n equal to 0 or 1; X: O, NR'1; A: COOH, optionally substituted aryl, cationic or non-cationic, saturated or unsaturated 5- or 6-membered heterocycle, comprising one or two heteroatoms, optionally substituted, alkyl, alkenyl; A2 divalent alkylene; the compounds possibly being, in the case of aldehydes, in acetal or hemiacetal form. The invention also relates to a process using such a composition, and also to multi-compartment devices.
• [EN] DYE COMPOSITION COMPRISING A NON-GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICE THEREFOR<br/>[FR] COMPOSITION DE COLORANT COMPRENANT UN COMPOSÉ IRIDOÏDE NON GLYCOSYLÉ ET UN ALDÉHYDE OU UNE IMINE PARTICULIER, PROCÉDÉ DE COLORATION ET DISPOSITIF ASSOCIÉ
  申请人：OREAL

  公开号：WO2013045703A1

  公开（公告）日：2013-04-04

  The present invention relates to a composition for dyeing human keratin fibres, comprising, in a cosmetically acceptable medium: a compound of formula (I) and/or of formula (II) below, or a plant extract comprising the same: with R1 : hydrogen, (hydroxy)methyl, aldehyde, -CO2R4 and R4: hydrogen, alkyl, - CH2-glucose; R2: hydrogen, hydroxyl, glucose; R3: hydrogen, hydroxyl, alkyloxy; n ranging from 1 to 5; R5: -C02R'6 and R'6: hydrogen, alkyl, cation; at least one aldehyde or imine compound of formulae (i) and (ii), and also oxidized oligo- or polysaccharide comprising at least one aldehyde or imine function: with n equal to 0 or 1; X: O, NR'-1; A: COOH, optionally substituted aryl, cationic or non-cationic, saturated or unsaturated 5- or 6-membered heterocycle, comprising one or two heteroatoms, optionally substituted, alkyl, alkenyl; A2 divalent alkylene; the compounds possibly being, in the case of aldehydes, in acetal or hemiacetal form. A subject of the invention is also a process using such a composition and a multicompartment device comprising a first compartment containing at least one compound of formula (I) and/or (II) or a plant extract comprising the same, and a second compartment containing at least one compound of formula (i) or (ii), an oxidized oligo- or polysaccharide comprising at least one aldehyde or imine function.
• [EN] SUBSTITUTED 2-AMINO PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIMIDINE À SUBSTITUTION 2-AMINO SERVANT DE COMPOSÉS INHIBITEURS DE KINASE
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2014106800A2

  公开（公告）日：2014-07-10

  The present invention provides novel substituted 2-amino pyrimidine derivatives kinase enzyme inhibitor compounds of formula (1), which may be therapeutically useful kinase inhibitor, more particularly PI3K inhibitors. Formula (1) in which A, R1, R2 R3. R4, Q and 'n' have the same meanings given in the specification, and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly PI3K enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.