1-(4-(2-phenoxyquinolin-3-yl)phenyl)ethanone | 1254212-04-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(4-(2-phenoxyquinolin-3-yl)phenyl)ethanone
• 英文别名: 1-[4-(2-Phenoxyquinolin-3-yl)phenyl]ethanone
• CAS: 1254212-04-8
• 化学式: C₂₃H₁₇NO₂
• 分子量: 339.393
• InChiKey: LLCRWKLVXVFILX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-((2-isocyanophenyl)ethynyl)phenyl)ethan-1-one 、 苯酚 在 三乙烯二胺 作用下， 以 二氯甲烷 为溶剂， 反应 21.0h， 生成 1-(4-(2-phenoxyquinolin-3-yl)phenyl)ethanone
  参考文献：
  名称：

  Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of o-Alkynylaryl Isocyanides

  摘要：

  Diversified 2-alkoxy- and 2-aroxy-3-substituted quinolines were synthesized from o-alkynylaryl isocyanides and alcohols and phenols promoted by DABCO, respectively. The reaction was initiated by nucleophilic addition of DABCO to isocyanide and subsequent cycliztion, leading to a DABCO-quinoline-based adduct as the reactive intermediate, followed by substitution of the DABCO moiety with oxygenated nucleophiles.

  DOI：

  10.1021/jo1017525

文献信息

• Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of <i>o</i>-Alkynylaryl Isocyanides
  作者：Jiaji Zhao、Changlan Peng、Lanying Liu、Yong Wang、Qiang Zhu

  DOI：10.1021/jo1017525

  日期：2010.11.5

  Diversified 2-alkoxy- and 2-aroxy-3-substituted quinolines were synthesized from o-alkynylaryl isocyanides and alcohols and phenols promoted by DABCO, respectively. The reaction was initiated by nucleophilic addition of DABCO to isocyanide and subsequent cycliztion, leading to a DABCO-quinoline-based adduct as the reactive intermediate, followed by substitution of the DABCO moiety with oxygenated nucleophiles.