Cambridge id 5571709

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Cambridge id 5571709
• 英文别名: 7-chloro-4-methyl-2-(4-methyl-1,4-diazepan-1-yl)quinoline
• 化学式: C₁₆H₂₀ClN₃
• 分子量: 289.8
• InChiKey: HYKNYFJFLPXZRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  19.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Compositions and methods for modulating gated ion channels
  申请人：Babinski Kazimierz

  公开号：US20070197509A1

  公开（公告）日：2007-08-23

  The present invention relates to compositions and methods to modulate the activity of gated ion channels.

  本发明涉及用于调节门控离子通道活性的组合物和方法。
• Identification of CDKI pathway inhibitors
  申请人：Chang Bey-Dih

  公开号：US20080033000A1

  公开（公告）日：2008-02-07

  The invention relates to the inhibition of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.
• [EN] METABOLIC KINASE MODULATORS AND METHODS OF USE AS PESTICIDES<br/>[FR] MODULATEURS METABOLIQUES DE KINASES ET LEURS PROCEDES D'UTILISATION EN TANT QUE PESTICIDES
  申请人：EXELIXIS INC

  公开号：WO2005087742A1

  公开（公告）日：2005-09-22

  This invention relates to compounds that can be used as pesticides, in particular their use as agents in the control of pests for crop protection, human and animal health, and home and garden applications. More specifically, this invention relates to the use of compounds that modulate metabolic kinase pathways of pests, in particular that inhibit the ethanolamine kinase pathways of pests, the disruption of which proves lethal.
• [EN] COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS<br/>[FR] COMPOSITIONS ET PROCEDES DE MODULATION DE CANAUX IONIQUES COMMANDES PAR PORTE
  申请人：PAINCEPTOR PHARMA CORP

  公开号：WO2007071055A1

  公开（公告）日：2007-06-28

  [EN] Disclosed are quinoline and qumazolme compounds which modulate the activity of the gated ion channels Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pam, inflammation, the neurological system, the gastrointestinal system and genitourinary system Preferred compounds include quinoline or qumazolme derivatives substituted at the 4- position via N(H), C(O) or O moieties
  [FR] L'invention concerne des composés de quinoléine et de quinazoline qui modulent l'activité des canaux ioniques commandés par porte. Les composés qui modulent ces canaux ioniques commandés par porte sont utilisés dans le traitement de maladies et de troubles relatifs à la douleur, l'inflammation, au système neurologique, au système gastro-intestinal et au système génito-urinaire. On mentionne comme composés préférés de l'invention des dérivés de la quinoléine ou de la quinazoline substitués en position 4, via des fractions N(H), C(O) ou O.