3,4-diformyl-2,5-dimethylfuran | 28883-88-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4-diformyl-2,5-dimethylfuran
• 英文别名: 2,5-dimethylfuran-3,4-dicarbaldehyde；2,5-Dimethylfuran-3,4-dicarbaldehyde
• CAS: 28883-88-7
• 化学式: C₈H₈O₃
• 分子量: 152.15
• InChiKey: YENQMGBSZLEUQR-UHFFFAOYSA-N

物化性质

• 沸点：
  264.8±40.0 °C(predicted)
• 密度：
  1.187±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-diformyl-2,5-dimethylfuran 、 4-thia-1,7-methano[11]annulene-2,6-dione 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以34%的产率得到1,3-dimethyl anti-3,11-epithia-7,12-methanofuro[3,4-e][14]annulene-5,13-dione
  参考文献：
  名称：

  Zuo, Shengli; Kuroda, Shigeyasu; Oda, Mitsunori, Heterocycles, 2001, vol. 54, # 1, p. 159 - 170

  摘要：

  DOI：

文献信息

• Facile Construction of Furan-Fused Methano[11]annulenone Skeleton by Successive Aldol Condensations from 3,4-Furandicarbaldehydes
  作者：Shigeyasu Kuroda、Yanmei Zhang、Nobuhiko Takezawa、Yosikazu Horino、Ayumi Takai、Yasutomo Tsuji、Ryuta Miyatake、Mitsunori Oda

  DOI：10.3987/com-08-s(f)52

  日期：——

  Aldol condensation of furan-3,4-dicarbaldehyde with pentanedial in acetic acid gave 6H-cyclohepta[c]furan-5,7-dicarbaldehyde in a good yield. Then, successive condensation of 6H-cyclohepta[c]furan-5,7-dicarbaldehyde with dimethyl 1,3 -acetonedicarboxylate under azeotropic conditions gave a diester derivative of furan-fused methano[11]annulenone also in a good yield. The hydrolysis of the diester groups and subsequent decarboxylation provided a non-substituted furan-fused methano[11]annulenone. A similar sequence starting from 2,5-dimethylfuran-3,4-dicarbaldehyde gave its dimethyl derivative. Cycloaddition and protonation of these furan-fused methano[11]annulenones were also studied.
• US7582712B1
  申请人：——

  公开号：US7582712B1

  公开（公告）日：2009-09-01
• Zuo, Shengli; Kuroda, Shigeyasu; Oda, Mitsunori, Heterocycles, 2001, vol. 54, # 1, p. 159 - 170
  作者：Zuo, Shengli、Kuroda, Shigeyasu、Oda, Mitsunori、Kuramoto, Shin-Ya、Mizukami, Yoshihiro、Fukuta, Atsushi、Hirano, Yukiyasu、Nishikawa, Teruhiko、Furuta, Shinji、Miyatake, Ryuta、Shaheen、Kajioka, Takanori、Kyogoku, Mayumi

  DOI：——

  日期：——