N-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-2-hydroxybenzamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-2-hydroxybenzamide
• 化学式: C₁₆H₁₃NO₅
• 分子量: 299.28
• InChiKey: FONHTANVJZLRTJ-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• TREATING MUSCULAR DISORDERS AND IMPROVING MUSCULAR FUNCTION
  申请人：DSM IP Assets B.V.

  公开号：EP2019720A2

  公开（公告）日：2009-02-04
• NOVEL USE OF ORGANIC COMPOUNDS
  申请人：D'Orazio Daniel

  公开号：US20100041746A1

  公开（公告）日：2010-02-18

  The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle:fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
• [EN] NOVEL USE OF ORGANIC COMPOUNDS<br/>[FR] NOUVELLE UTILISATION DE COMPOSÉS ORGANIQUES
  申请人：DSM IP ASSETS BV

  公开号：WO2007134867A2

  公开（公告）日：2007-11-29

  [EN] The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy,, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle : fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
  [FR] La présente invention concerne des composés représentés par les formules générales Ia à Ie, telles que définies dans les descriptions destinés à être utilisés comme composition ou dans une composition (en particulier des suppléments alimentaires et diététiques, des cosmétiques ainsi que des compositions pharmaceutiques) pour la prévention et l'amélioration de troubles musculaires et pour l'amélioration de la fonction du muscle. D'autres domaines d'utilisation recouvrent des troubles liés au métabolisme des lipides altéré, au métabolisme du glucose altéré et à l'action de l'insuline altérée, à l'obésité, au sur poids, des troubles alimentaires tels que la boulimie et l'anorexie, des maladies cardio-vasculaires, l'athérosclérose, des maladies vasculaires, l'insuffisance cardiaque, des troubles inflammatoires tels que l'arthrite, l'arthrite rhumatoïde, l'ostéoporose, la goutte, des troubles du tube digestif tels que le syndrome intestinal inflammatoire, la maladie de Crohn, la gastrite, le syndrome du colon irritable et la rectocolite hémorragique, des pathologies cutanées telles que le psoriasis, l'eczéma, les brûlures, la dermatite et l'allergie, des troubles respiratoires tels que l'asthme, la broncopneumopathie obstructive chronique (COPD), des maladies allergiques et/ou des pathologies osseuses telles que l'ostéoporose et l'ostéopénie. Ces composés peuvent aussi être utilisés pour modeler le corps, améliorer le rapport muscle sur masse grasse ou pour accélérer la guérison de blessures cutanées. La présente invention concerne aussi des compositions diététiques telles que des aliments (fortifiés), des boissons, des aliments pour animaux (fortifiés), des additifs alimentaires, des additifs pour boisson, des additifs pour aliments pour animaux, une nutrition clinique, des suppléments diététiques, des aliments fonctionnels, des aliments fonctionnels pour animaux et des nutraceutiques, ainsi que des compositions pharmaceutiques contenant ces composés, des procédés de traitement des troubles/maladies susmentionnés chez des mammifères, y compris chez des humains, et les composés représentés par la formule I eux-même. Un autre objet de cette invention est l'utilisation de ces composés dans la fabrication d'une composition destinée au traitement des troubles/maladies susmentionnées.
• [EN] SCREENING METHOD FOR EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR AND INHIBITORS IDENTIFIED USING SAME<br/>[FR] PROCÉDÉ DE RECHERCHE SYSTÉMATIQUE DE L'INHIBITEUR DE LA TYROSINE KINASE DU RÉCEPTEUR DU FACTEUR DE CROISSANCE ÉPIDERMIQUE
  申请人：UNIV HOSEO ACAD COOP FOUND

  公开号：WO2010107156A1

  公开（公告）日：2010-09-23

  본 발명은 단백질 칩 상에 EGFR 타이로신 키나제에 의해 활성화될 수 있는 EGFR 타이로신 키나제 기질(substrate)을 부착하고, 상기 기질이 부착된 단백질 칩에 EGFR 타이로신 키나제, ATP, Mg2+ 및 단일 화합물 라이브러리의 화합물 풀(pool)을 반응시킴으로서, EGFR 타이로신 키나아제의 활성을 우수하게 억제할 수 있는 새로운 억제물질을 대량으로 신속하게 탐색할 수 있는 것이다.