8-[(3,4-Dichlorophenyl)methoxy]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-[(3,4-Dichlorophenyl)methoxy]quinoline
• 化学式: C₁₆H₁₁Cl₂NO
• 分子量: 304.2
• InChiKey: QNORFXFZXDKUHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIENE-11-ETHYNYLPHENYL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING DISEASES
  申请人：Klar Ulrich

  公开号：US20120190660A1

  公开（公告）日：2012-07-26

  The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-diene 11-ethynylphenyl derivatives of the formula I, in which R 1 and X are each as defined in the claims and the description, and to a process for preparation thereof and to the use thereof as medicaments.

  该发明涉及式I中的17-羟基-17-五氟乙基雌二烯-4,9(10)-二烯-11-乙炔基苯基衍生物，其中R1和X如索赔和描述中所定义，以及其制备方法和用作药物的用途。
• Method of preparing a composition containing hygromycin A and epi-hygromycin
  申请人：Pfizer Products Inc.

  公开号：EP1369490A1

  公开（公告）日：2003-12-10

  A method of preparing a composition containing hygromycin A and epi-hygromycin, wherein the ratio of hygromycin A to epi-hygromycin is at least 10:1, which comprises fermenting Streptomyces hygroscopicus in media having a pH less than 6.9 at a temeperature ranging from 25°C to 35°C.

  一种制备含百日咳霉素 A 和表-百日咳霉素的组合物的方法，其中百日咳霉素 A 与表-百日咳霉素的比例至少为 10:1，该方法包括在 pH 值小于 6.9 的培养基中，在 25°C 至 35°C 的温度范围内发酵吸湿链霉菌。
• HYGROMYCIN A DERIVATIVES
  申请人：Pfizer Products Inc.

  公开号：EP1075483B1

  公开（公告）日：2003-12-03
• 2"-DEOXY HYGROMYCIN DERIVATIVES
  申请人：Pfizer Products Inc.

  公开号：EP1077984A1

  公开（公告）日：2001-02-28
• Methods of Inhibiting Multiple Cytochrome P450 Genes with siRNA
  申请人：Baldwin William S.

  公开号：US20090265795A1

  公开（公告）日：2009-10-22

  The present invention relates to siRNAs that are targeted to RNAs encoding two or more enzymes of a subfamily of cytochrome P450 (CYP) enzymes, along with vectors, cells, and kits comprising the siRNAs. The invention further relates to methods of decreasing expression of two or more CYP subfamily genes in a non-human animal, animals in which expression of two or more CYP subfamily genes has been decreased, and methods of using such animals to study the function of cytochrome P450 enzymes.