N-(2-furylmethyl)-2-methyl-N-[(8-methyl-2-oxo-1H-quinolin-3-yl)methyl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-furylmethyl)-2-methyl-N-[(8-methyl-2-oxo-1H-quinolin-3-yl)methyl]benzamide
• 英文别名: N-(furan-2-ylmethyl)-2-methyl-N-[(8-methyl-2-oxo-1H-quinolin-3-yl)methyl]benzamide
• 化学式: C₂₄H₂₂N₂O₃
• 分子量: 386.4
• InChiKey: DYKLFFCVLKUQEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Small Molecule Inhibitors of Retroviral Assembly and Maturation
  申请人：Debnath Asim Kumar

  公开号：US20100035912A1

  公开（公告）日：2010-02-11

  Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.
• US8299093B2
  申请人：——

  公开号：US8299093B2

  公开（公告）日：2012-10-30
• US8546439B2
  申请人：——

  公开号：US8546439B2

  公开（公告）日：2013-10-01
• [EN] SMALL MOLECULE INHIBITORS OF RETROVIRAL ASSEMBLY AND MATURATION<br/>[FR] INHIBITEURS À PETITE MOLÉCULE D'ASSEMBLAGE ET DE MATURATION RÉTROVIRAUX
  申请人：NEW YORK BLOOD CT INC

  公开号：WO2010017355A2

  公开（公告）日：2010-02-11

  Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.