(E)-3-(2-chlorophenyl)-N-(4-piperidin-1-ylsulfonylphenyl)prop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(2-chlorophenyl)-N-(4-piperidin-1-ylsulfonylphenyl)prop-2-enamide
• 化学式: C₂₀H₂₁ClN₂O₃S
• 分子量: 404.9
• InChiKey: PUNYXJGURUKZFW-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Neuroprotective small organic molecules, compositions and uses of related thereto
  申请人：Lin Leu-Fen H.

  公开号：US20090227790A1

  公开（公告）日：2009-09-10

  The present application is directed to therapeutic compounds, compositions, and methods for culturing neuronal cells and for preventing and the treatment of neurodegenerative diseases, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS).

  本申请涉及治疗化合物、组合物和培养神经细胞的方法，以及预防和治疗神经退行性疾病，如帕金森病和肌萎缩侧索硬化症（ALS）。
• Compounds affecting pigment production and methods for treatment of bacterial diseases
  申请人：Versitech Limited

  公开号：US11040949B2

  公开（公告）日：2021-06-22

  Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

  本文提供了化合物、其衍生物、包含一种或多种所述化合物和衍生物的组合物，以及预防和/或治疗微生物感染和/或相关疾病或病症的方法。本化合物和/或其衍生物可由式 (II) 表示： 本方法包括向受试者施用有效量的一种或多种式（II）化合物。在一个实施方案中，所述微生物感染是细菌感染。更具体地说，所述细菌感染是葡萄球菌感染。
• COMPOUNDS AFFECTING PIGMENT PRODUCTION AND METHODS FOR TREATMENT OF BACTERIAL DISEASES
  申请人：Versitech Limited

  公开号：US20200261438A1

  公开（公告）日：2020-08-20

  Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.
• US7671077B2
  申请人：——

  公开号：US7671077B2

  公开（公告）日：2010-03-02
• US7786125B2
  申请人：——

  公开号：US7786125B2

  公开（公告）日：2010-08-31