3-(2-(benzofuran-2-yl)-4H-chromen-4-yl)-1H-indole | 1575402-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2-(benzofuran-2-yl)-4H-chromen-4-yl)-1H-indole
• 英文别名: 3-[2-(1-benzofuran-2-yl)-4H-chromen-4-yl]-1H-indole
• CAS: 1575402-33-3
• 化学式: C₂₅H₁₇NO₂
• 分子量: 363.415
• InChiKey: LYVYHKZFWORLBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  38.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吲哚 、 2-乙酰基苯并呋喃 、 水杨醛 在 L-脯氨酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 8.0h， 以58%的产率得到3-(2-(benzofuran-2-yl)-4H-chromen-4-yl)-1H-indole
  参考文献：
  名称：

  2-Methylindole as an Indicative Nucleophile for Developing a Three-Component Reaction of Aldehyde with Two Different Nucleophiles

  摘要：

  2-Methylindole was used as an indicative nucleophile for rapid screening of MCRs of aldehydes with two different nucleophiles. By removal of some samples that have characteristic color associated with the generation of di(indolyOmethane derivatives the difficulties encountered in the product analysis were alleviated significantly.

  DOI：

  10.1021/co500010x

文献信息

• 2-Methylindole as an Indicative Nucleophile for Developing a Three-Component Reaction of Aldehyde with Two Different Nucleophiles
  作者：Dan Jiang、Xiaojuan Pan、Minghao Li、Yanlong Gu

  DOI：10.1021/co500010x

  日期：2014.6.9

  2-Methylindole was used as an indicative nucleophile for rapid screening of MCRs of aldehydes with two different nucleophiles. By removal of some samples that have characteristic color associated with the generation of di(indolyOmethane derivatives the difficulties encountered in the product analysis were alleviated significantly.