肟菌酯 | 141517-21-7

• 物质功能分类: 化学农药原药 - 杀菌剂 - 其他杀菌剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 肟菌酯
• 中文别名: 肟草酯；三氟敏；(2Z)-2-甲氧基亚氨基-2-[2-[[1-[3-(三氟甲基)苯基]亚乙基氨基]氧甲基]苯基]乙酸甲酯；(E)-α-甲氧亚氨基-2-[(E)-1-(3-三氟甲苯基)亚乙基氨基氧甲基]苯乙酸甲酯；肟菌脂
• 英文名称: trifloxystrobin
• 英文别名: methyl (E)-methoxyimino-{(E)-α-[1-(α,α,α-trifluoro-m-tolyl)ethylideneaminooxy]-o-tolyl}acetate；methyl (2E)-2-methoxyimino-2-[2-[[(E)-1-[3-(trifluoromethyl)phenyl]ethylideneamino]oxymethyl]phenyl]acetate
• CAS: 141517-21-7
• 化学式: C₂₀H₁₉F₃N₂O₄
• 分子量: 408.377
• InChiKey: ONCZDRURRATYFI-TVJDWZFNSA-N

物化性质

• 熔点：
  72.9°
• 沸点：
  bp~312°
• 密度：
  1.21±0.1 g/cm3(Predicted)
• 闪点：
  >70 °C
• 溶解度：
  氯仿：微溶；甲醇：微溶
• LogP：
  5.112 (est)
• 颜色/状态：
  White powder
• 气味：
  Odorless
• 蒸汽压力：
  2.55X10-8 mm Hg at 25 °C
• 稳定性/保质期：
  No change after 2 years storage at 20 °C in commercial packing. /Stratego 250 EC/ /from table/
• 分解：
  Decompn starting at 285 °C.
• 解离常数：
  Trifloxystrobin does not show any dissociation in the pH ranges 2 to 12.

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  69.5
• 氢给体数：
  0
• 氢受体数：
  9

ADMET

代谢

在大鼠中，吸收的化合物通过广泛的代谢迅速清除，尤其是通过酯基的水解。其他重要的代谢途径包括甲氧基亚硝基团的O-脱甲基化和甲基侧链的氧化，生成相应的醇和羧酸。

In rats, the absorbed compound was rapidly cleared with extensive metabolism, particularly through hydrolysis of the ester group. Other significant metabolic routes were O-demethylation of the methoxyimino group and oxidation of the methyl side chain to the corresponding alcohol and carboxylic acid.

来源:Hazardous Substances Data Bank (HSDB)

代谢

雄性和雌性大鼠通过灌胃给予[Glyoxyl-Phenyl-(U)-14C]（放射性化学纯度范围：>97至>99%）或[Trifluormethyl-Phenyl-(U)-14C]-/trifloxystrobin/（CGA-279202）（放射性化学纯度：>99%）。除了D2组外，所有组的动物都给予了[Glyoxyl-Phenyl-(U)-14C]-/trifloxystrobin/（CGA 279202）...从尿液、粪便和胆汁样本中分离并鉴定了35种代谢物。主要的代谢途径包括1）甲基酯水解成相应的酸，2）甲氧基亚氨基的O-去甲基化，以及3）甲基侧链氧化成初级醇，随后进一步氧化成羧酸。最后一种反应在雌性大鼠中是一个更突出的代谢途径，导致了主要性别特异性尿代谢物的分离。甘氧基-苯基和三氟甲基-苯基部分的裂解占总剂量的10%。对于三氟甲基苯基片段，羟基亚氨基的氧化导致了硝基化合物的形成，甲基的氧化导致了羧酸的形成。此外，亚氨基的水解形成了一个中间酮，随后的反应最终导致了三氟甲基苯甲酸的形成。对于甘氧基-苯基部分，氧化导致了苯甲酸的形成。甲氧基亚氨基的O-去甲基化导致了羟基亚氨基化合物。亚氨基的水解产生了α-酮酸，随后通过脱羧作用转化为邻苯二甲酸。胆汁中分离出了与葡萄糖醛酸或硫酸结合的共轭物。低剂量和高剂量的4%至7%和31%至47%分别以未代谢的测试材料形式在粪便中排出。吸收的剂量主要在胆汁中分离。进一步的加工将测试材料及其代谢物返回到肠道，并通过粪便排出或通过肠肝循环再吸收。

Male and female rats were dosed by gavage with either [Glyoxyl-Phenyl-(U)-14C] (radiochemical purity range: >97 to >99%) or [Trifluormethyl-Phenyl-(U)-14C]-/trifloxystrobin/ (CGA- 279202) (radiochemical purity: >99%). For all of the groups except D2, the animals were dosed with [Glyoxyl-Phenyl-(U)-14C]-/trifloxystrobin/ (CGA 279202). ...Thirty five metabolites were isolated and identified from the urine, feces and bile samples. Major metabolic pathways included 1) hydrolysis of the methyl ester to the corresponding acid, 2) O-demethylation of the methoxyimino group, and 3) oxidation of the methyl side chain to a primary alcohol, followed by further oxidation to the carboxylic acid. This last reaction was a more prominent metabolic pathway in the female rats with the resultant isolation of major sex-specific urinary metabolites. Cleavage of the glyoxyl-phenyl and trifluoromethyl-phenyl moieties accounted for 10% of the dose. For the trifluoromethyl phenyl fragment, oxidation of the hydroxyimino group led to the formation of a nitro compound and oxidation of the methyl group resulted in the formation of the carboxylic acid. In addition, hydrolysis of the imino group formed an intermediate ketone with succeeding reactions ultimately leading to trifluoromethyl benzoic acid. For the glyoxyl-phenyl moiety, oxidation resulted in the formation of a benzoic acid. O-demethylation of the methoxyimino group resulted in the hydroxyimino compound. Hydrolysis of the imino group yielded the a-keto acid followed by decarboxylation to the phthalic acid. Conjugates with glucuronide or sulfate were isolated from the bile. Four to 7% and 31 to 47% of the low and high doses, respectively, were eliminated in feces as the unmetabolized test material. The absorbed dose was predominantly isolated in the bile. Further processing returned the test material and/or metabolites to the intestinal tract and elimination in the feces or reuptake via the enterohepatic pathway.

来源:Hazardous Substances Data Bank (HSDB)

代谢

三氟菌唑的主要代谢途径包括：1）甲基酯水解为相应的酸，2）甲氧基亚硝基团的脱甲基化，3）甲基侧链氧化为一级醇，随后进一步氧化为羧酸。代谢物通过粪便排出。

Major metabolic pathways of trifloxystrobin included 1) hydrolysis of the methyl ester to he corresponding acid, 2) O-demethylation of the methoxyimino group, and 3) oxidation of the methyl side chain to a primary alcohol, followed by further oxidation to the carboxylic acid. Metabolites are excreted in the feces.

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

三氟菌唑是一种白色粉末。它被用作农业杀菌剂。人类接触和毒性：如果三氟菌唑通过皮肤吸收，对人体有害。长期或频繁的皮肤接触可能会使一些人产生过敏反应。动物研究：在小鼠和大鼠口服、家兔皮肤接触以及大鼠吸入途径中，三氟菌唑被认为是低急性毒性的。在大鼠急性灌胃或亚慢性饮食给药后，三氟菌唑并未表现出选择性的神经毒性。在大鼠中，处理与交配、生育或窝仔数无关。在S. typhimurium TA98、TA100、TA102、TA1535或TA1357菌株以及E. coli WP2 uvrA菌株（无论是否经过代谢激活）中，三氟菌唑不具有诱变性。生态毒性研究：三氟菌唑对非目标水生生物有毒。三氟菌唑可能会影响抗氧化酶的活性，干扰小球藻的光合作用，并损害细胞结构。三氟菌唑对鱼类胚胎高度有毒。对水蚤（Daphnia magna）非常有毒，即使在环境相关的浓度下也可能对其造成伤害。三氟菌唑对羊头鱼（sheepshead minnows）极为有毒。

IDENTIFICATION AND USE: Trifloxystrobin is a white powder. It is used as agricultural fungicide. HUMAN EXPOSURE AND TOXICITY: Trifloxystrobin is harmful if absorbed through skin. Prolonged or frequently repeated skin contact may cause allergic reactions in some individuals. ANIMAL STUDIES: Trifloxystrobin was considered to be of low acute toxicity by the oral route in mice and rats, by the dermal route in rabbits, and by the inhalation route in rats. Trifloxystrobin was not selectively neurotoxic following acute gavage or subchronic dietary administration in rats. There were no treatment-related effects upon the mating, fertility, or litter size in rats. It was not mutagenic in S. typhimurium strains TA98, TA100, TA102, TA1535, or TA1357, or in E. coli strain WP2 uvrA with and without metabolic activation. ECOTOXICITY STUDIES: Trifloxystrobin is toxic to nontarget aquatic organisms. Trifloxystrobin could affect the activities of antioxidant enzymes, disrupt photosynthesis in Chlorella vulgaris, and damage cellular structure. Trifloxystrobin is highly toxic to fish embryos. It is very toxic to Daphnia magna and can cause harm to D. magna at environmentally relevant concentrations. Trifloxystrobin was very highly toxic to sheepshead minnows.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：不太可能对人类致癌

Cancer Classification: Not likely to be carcinogenic to humans

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

暴露于戊菌隆可能会引起肝细胞肥大。

Exposure to Trifloxystrobin might cause hepatocellular hypertrophy.

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

职业暴露于三氟戊醇可能发生在生产或使用三氟戊醇的工作场所，通过吸入和皮肤接触这种化合物。

Occupational exposure to trifloxystrobin may occur through inhalation and dermal contact with this compound at workplaces where trifloxystrobin is produced or used.

来源:Toxin and Toxin Target Database (T3DB)

吸收、分配和排泄

雄性和雌性大鼠通过灌胃给药，分别给予[乙醛氧基-苯基-(U)-^(14)C]（比活度范围：54.3至63.5 uCi/mg，放射化学纯度范围：>97至>99%）或[三氟甲基-苯基-(U)-^(14)C]/三氟噁唑菌（CGA-279202）（比活度：59.2 uCi/mg，放射化学纯度：>99%）。除了D2组外，所有组的大鼠都给予了[Glyoxyl-Phenyl-(U)-(14)C]-/三氟噁唑菌/（CGA 279202）。在B1和D1组中，收集了5只/性别，分别以0.5或100 mg/kg的测试材料给药的大鼠的尿液和粪便样本，收集时间长达7天。对于C1组，5只/性别的动物预先以0.5 mg/kg的无标记/三氟噁唑菌/（CGA 279202）（纯度：99.7%）处理14天，随后给予0.5 mg/kg的标记测试材料。同样，这些动物的尿液和粪便样本也被收集，时间长达7天。在D2组中，5只/性别的动物给予100 mg/kg的[Trifluormethyl-Phenyl-(U)-(14)C]/三氟噁唑菌/（CGA-279202），并收集尿液和粪便样本长达7天。在F1和5组以及F2和6组中，分别有12只/性别的动物给予0.5或100 mg/kg的测试材料。根据之前组别的药代动力学测定，在4个时间点确定了组织残留量。G组动物的门静脉进行了插管。在G1和3组中，6只雄性和5只雌性以0.5 mg/kg的测试材料处理。在G2和4组中，分别有6只雄性和4只雌性给予100 mg/kg的测试材料。在低剂量水平，吸收了56至65%的剂量，其中41至47%的剂量从胆汁中回收。在高剂量组中，吸收了25至45%的剂量，其中19至35%的剂量从胆汁中回收。在低剂量处理中，雄性大鼠的尿液中排泄了18至19%的剂量，粪便中排泄了79%的剂量。对于雌性大鼠，尿液中有35至42%被排泄，粪便中有56至63%被排泄。预先用无标记测试材料处理并没有改变排泄模式。在高剂量组中，雄性大鼠在尿液和粪便中分别排泄了10至12%和82至84%。雌性大鼠在尿液中排泄了27%，在粪便中排泄了64至66%。D2组动物呼出的气体中回收到的放射性标记物非常少。组织中的放射性标记物衰减的半衰期从13至42小时不等，除了高剂量雌性的脾脏和血液（分别为68和82小时）。血液中测试材料达到最大浓度的 times 是给药后12至24小时。达到最大浓度的时间范围是给药后23至67小时。给药7天后，尸体残留的放射性标记物非常少，仅回收了0.3至0.5%的给药剂量。

Male and female rats were dosed by gavage with either [Glyoxyl-Phenyl-(U)-(14)C] (spec. act. range: 54.3 to 63.5 uCi/mg, radiochemical purity range: >97 to >99%) or [Trifluormethyl-Phenyl-(U)-14C] /trifloxystrobin/ (CGA- 279202) (spec. act.: 59.2 uCi/mg, radiochemical purity: >99%). For all of the groups except D2, the animals were dosed with [Glyoxyl-Phenyl-(U)-(14)C]-/trifloxystrobin/ (CGA 279202). In Groups B1 and D1, urine and feces samples were collected up to 7 days from 5 animals/sex dosed with 0.5 or 100 mg/kg of the test material, respectively. For Group C1, 5 animals/sex were pretreated for 14 days with 0.5 mg/kg of unlabelled /trifloxystrobin/ (CGA 279202) (purity: 99.7%), followed by 0.5 mg/kg of the labelled test material. Urine and feces samples were likewise collected from these animals for up to 7 days. In Group D2, 5 animals/sex were dosed with 100 mg/kg of [Trifluormethyl-Phenyl-(U)-(14)C] /trifloxystrobin/ (CGA-279202) and urine and feces samples were collected up to 7 days. Twelve animals/sex were dosed with either 0.5 or 100 mg/kg of the test material in Groups F1 and 5 and Groups F2 and 6, respectively. Tissue residues were determined at 4 time points based upon pharmacokinetic determinations derived from the previous groups. The bile ducts of animals in Group G were cannulated. In Groups G1 and 3, 6 males and 5 females were treated with 0.5 mg/kg of the test material. Six males and 4 females were dosed with 100 mg/kg of the test material in Groups G2 and 4, respectively. At the low dose level, 56 to 65% of the dose was absorbed with 41 to 47% of the dose recovered from the bile. In the high dose group, 25 to 45% of the dose was absorbed with 19 to 35% of the dose recovered from the bile. In the low dose treatment, 18 to 19% and 79% of the dose was excreted in the urine and feces, respectively, of the males. For the females, 35 to 42% was excreted in the urine and 56 to 63% in the feces. Pretreatment with unlabelled test material did not alter the pattern of excretion. In the high dose groups, the males excreted 10 to 12% and 82 to 84% in the urine and feces, respectively. The females excreted 27% in the urine and 64 to 66% in the feces. Very minimal levels of radiolabel were recovered from the expired air of the animals in Group D2. The half lives for the depletion of radiolabel from the tissues ranged from 13 to 42 hours except for the spleen and blood of the high dose females (68 and 82 hours, respectively). The times to maximal concentration of the test material in the blood were either 12 to 24 hours after dosing. The times to maximal concentration ranged from 23 to 67 hours after dosing. Residual retention of the radiolabel in the carcass after 7 days was very minimal with 0.3 to 0.5% of the dose administered recovered.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

三氟苯嘧啶从胃肠道中度吸收并迅速分布。在低剂量组中，大约56%和65%的给药剂量（AD）分别被雄性和雌性吸收（基于尿液、粪便、胆汁和组织的总回收量），其中胆汁中分别有41%和47%。在高剂量组中，吸收率为41%和27%，而胆汁含量分别为35%和19%，分别对应雄性和雌性。血液动力学显示，在两个剂量组中，两性的吸收率均为中等，有两个峰值（低剂量在0.5小时和12小时后，高剂量在12小时和24小时后）。血液、肾脏、脾脏和肝脏中的残留物最高，且两性之间相似。放射性的排泄是迅速的。大约85-96%的剂量在48小时内被排出。排泄途径受动物性别的影响，雌性通过尿液排出的量是雄性的两倍，分别占剂量的27-42%和12-19%。通过粪便排出的量分别为雄性的79-82%和雌性的56-64%。在两性中，胆汁排泄是主要的排泄途径。消除过程中存在肠肝循环旁路的参与。

Trifloxystrobin was moderately absorbed from the gastrointestinal tract and rapidly distributed. In the low-dose group, approximately 56% and 65% administered dose (AD) was absorbed in males and females respectively (based on the total recovery from urine, feces, bile and tissues), with 41 and 47% being in bile of males and females, respectively. In the high-dose, group, the degree of absorption was 41 and 27%, while the bile content was 35% and 19%, respectively for males and females. The blood kinetics revealed a moderate absorption rate in both sexes with two peaks (after 0.5 and 12 hours at the low dose and 12 and 24 hours at the high dose). The highest residues were found in blood, kidneys, spleen and liver and were comparable between sexes. Excretion of the radioactivity was rapid. Approximately 85-96% of the dose was excreted within 48 hours. The route of elimination was influenced by the sex of the animals, females eliminated twice the amount with the urine than males, accounting for 27-42% and 12-19% of the dose, respectively. The amounts excreted via feces were 79-82% and 56-64% of the dose in males and females, respectively. In both sexes biliary excretion was the major route of elimination. The involvement of an enterohepatic shunt mechanism in the elimination process is indicated.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  Xi,N
• 安全说明：
  S24
• 危险类别码：
  R43
• WGK Germany：
  2
• 危险品运输编号：
  UN3077 9/PG 3

制备方法与用途

根据提供的信息，以下是对肟菌酯的主要特点和应用进行总结：

主要特点：

1. 化学性质：肟菌酯是一种甲氧基丙烯酸类杀菌剂，具有广谱的抗菌活性。
2. 作用机理：通过抑制细胞线粒体呼吸，从而阻止三磷酸腺苷（ATP）合成来发挥抑菌效果。
3. 抗药性管理：不单独使用，而是与化学结构和作用机制不同的三唑类杀菌剂戊唑醇混配使用，以延缓抗药性的产生。
4. 环境安全性：
   • 育鱼方面高毒、对水生生物风险较高。
   • 对鸟类、蜜蜂、家蚕和蚯蚓等非靶标生物低毒。
5. 合成路线：通过邻甲基苯胺为起始原料，经过一系列有机反应最终制得肟菌酯原药。

应用：

1. 作物病害防治：广泛用于防治黄瓜白粉病、炭疽病和番茄早疫等常见植物病害。
2. 混合制剂：常与戊唑醇混配使用，以提高杀菌效果并延缓抗性产生。
3. 施药方法及用量：
   • 施药剂量：每公顷112.5~168.75g有效成分（约150~225克/公顷水分散粒剂）。
   • 应用次数和间隔：一般在生长季节内使用3次，每次用药间隔为7天。在黄瓜和番茄上的最高施用量不超过每亩15克，安全间隔期为5天。

使用注意事项：

• 避免药液污染水源或通过其他方式进入水体。
• 注意保护蜜蜂、家蚕等敏感生物。
• 严格遵守推荐剂量使用，避免过量或频繁用药引起抗性问题。

综上所述，肟菌酯作为一种高效广谱的甲氧基丙烯酸类杀菌剂，在植物病害防治方面具有广泛应用前景。合理使用并结合其他化学物质混配可以提高药效同时降低潜在风险。

反应信息

• 作为反应物：
  描述：

  肟菌酯 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 sodium trifloxystrobin
  参考文献：
  名称：

  一种肟菌酯特征杂质的制备方法

  摘要：

  本发明提供一种肟菌酯特征杂质的制备方法，所述制备方法包括如下步骤：(1)肟菌酯与碱进行皂化反应，得到肟菌酸盐；(2)将肟菌酸盐与溴代肟醚进行缩合反应，生成的粗产物进行后处理，得到所述肟菌酯特征杂质。所述制备方法通过皂化和缩合两步反应快速合成肟菌酯特征杂质，工艺步骤简单，反应条件温和，易于操作，原料转化率高，无副反应发生；经过后处理得到的最终产物纯度大于98.5％，产率可达到87％以上。通过本发明提供的制备方法得到的肟菌酯特征杂质具有高纯度和高产率特点，可作为对照品，有利于肟菌酯分析方法的开发，更有利于肟菌酯的质量控制，为产品质量控制提供了新的思路。

  公开号：

  CN113527137A
• 作为产物：
  描述：

  2-hydroxy-2-(2-methylphenyl)acetonitrile 在 盐酸 、 N-溴代丁二酰亚胺(NBS) 、 sodium hypobromide 、 4-acetoxy-2,2,6,6-tetramethylpiperidine-1-oxyl 、 三光气 、 硫酸 、 四丁基溴化铵 、 水 、 溴 、 potassium carbonate 作用下， 以 二氯甲烷 、 水 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 39.5h， 生成 肟菌酯
  参考文献：
  名称：

  [EN] A NOVEL PROCESS FOR THE PREPARATION OF TRIFLOXYSTROBIN
  [FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE TRIFLOXYSTROBINE

  摘要：

  公开号：

  WO2017085747A4

文献信息

• [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
  申请人：GILEAD APOLLO LLC

  公开号：WO2017075056A1

  公开（公告）日：2017-05-04

  The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了化合物I和II，这些化合物可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及它们的组合物和使用方法。
• [EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
  申请人：BASF SE

  公开号：WO2014206910A1

  公开（公告）日：2014-12-31

  The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及公式（I）中变量如索权和说明中所定义的自行车基取代异噻唑啉化合物。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种通过使用这些化合物来控制无脊椎动物害虫的方法，以及包含所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] AZOLINE COMPOUNDS<br/>[FR] COMPOSÉS AZOLINE
  申请人：BASF SE

  公开号：WO2015128358A1

  公开（公告）日：2015-09-03

  The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式（I）的噁唑啉化合物，其中A、B1、B2、B3、G1、G2、X1、R1、R3a、R3b、Rg1和Rg2如权利要求和描述中所定义。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种利用这些化合物控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] SUBSTITUTED QUINAZOLINES AS FUNGICIDES<br/>[FR] QUINAZOLINES SUBSTITUÉES, UTILISÉES EN TANT QUE FONGICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2010136475A1

  公开（公告）日：2010-12-02

  The present invention relates to a compound of formula (I) wherein wherein the substituents have the definitions as defined in claim 1or a salt or a N-oxide thereof, their use and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

  本发明涉及一种具有如下式（I）的化合物，其中取代基具有权利要求1中定义的定义，或其盐或N-氧化物，它们的用途以及用于控制和/或预防植物中微生物感染，特别是真菌感染的方法，以及制备这些化合物的方法。
• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。