N,N-dibenzyl-4-oxo-1H-quinoline-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N-dibenzyl-4-oxo-1H-quinoline-3-carboxamide
• 化学式: C₂₄H₂₀N₂O₂
• 分子量: 368.4
• InChiKey: XBEAXEHFZLGHEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS
  申请人：Council of Scientific and Industrial Research

  公开号：US20180127373A1

  公开（公告）日：2018-05-10

  The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar 1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

  本专利披露了一种新颖的一锅两步法合成伊瓦卡托和相关化合物[式(I)]的过程，其中R1、R2、R3、R4、R5、R6、R7和Ar1如上所述；其互变异构体或药学上可接受的盐，起始物为吲哚乙酸酰胺。
• Process for the synthesis of ivacaftor and related compounds
  申请人：Council of Scientific and Industrial Research

  公开号：US10336703B2

  公开（公告）日：2019-07-02

  The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

  本专利公开了以吲哚乙酸酰胺为起始原料，合成伊伐卡夫多及相关化合物[式（I）]（其中 R1、R2、R3、R4、R5、R6、R7 和 Ar1 如上所述）及其同系物或药学上可接受的盐的一种新颖的一步法或两步法工艺。