N-[2-(4-sulfamoylphenyl)ethyl]-2-(thiophen-2-yl)quinoline-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[2-(4-sulfamoylphenyl)ethyl]-2-(thiophen-2-yl)quinoline-4-carboxamide
• 英文别名: N-[2-(4-sulfamoylphenyl)ethyl]-2-thiophen-2-ylquinoline-4-carboxamide
• 化学式: C₂₂H₁₉N₃O₃S₂
• mdl: MFCD05999926
• 分子量: 437.5
• InChiKey: QGHYISYCZNANMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR INHIBITION OF ROS
  申请人：GRUENEBERG Dorre A.

  公开号：US20160031890A1

  公开（公告）日：2016-02-04

  The present invention relates to a method using some novel compounds and compositions for the inhibition of ROS tyrosine kinase. In particular, the present invention covers a method to treat abnormal cell growth, such as cancer, with ROS 10 inhibitors and compositions having ROS inhibitors. An illustrative compound of the invention is shown below Formula (I).
• US9963452B2
  申请人：——

  公开号：US9963452B2

  公开（公告）日：2018-05-08