9-benzylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one | 146351-97-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-benzylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one
• 英文别名: 9-(benzylamino)-3,3-dimethyl-3,4-dihydroacridin-1(2H)-one；9-(benzylamino)-3,3-dimethyl-2,4-dihydroacridin-1-one
• CAS: 146351-97-5
• 化学式: C₂₂H₂₂N₂O
• mdl: MFCD00690560
• 分子量: 330.429
• InChiKey: UFEQPHYISGZSKN-UHFFFAOYSA-N

物化性质

• 沸点：
  522.9±50.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• DERIVATIVES OF 9-AMINOACRIDINE HAVING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID REGULATING PROPERTIES
  申请人：VSESOJUZNY NAUCHNY TSENTR PO BEZOPASNOTI BIOLOGICHESKI ACTIVNYKH VESHCHESTV

  公开号：EP0633251A1

  公开（公告）日：1995-01-11

  New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH₃; R¹ = H, CH₃, Br; R² = H, CH₃; R³ = alkyl-C₁-C₅, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH₂; X + Y = CH = CH; and their salts with organic and non-organic acids. The desired compounds are obtained by interaction of substituted nitriles of antranyl acid with dimedone with subsequent cyclization of intermediate enaminonitriles into corresponding ketones of 9-aminoacridine after the reduction of which and of their derivatives alkylated or aralkylated on the 9-amino group, the corresponding alcohols are obtained, after hydration of which 9-amino-3,4-dihydroacridines are obtained. When experimented on animals, the said derivatives of 9-aminoacridine have shown psychotropic, antiamnestic and lipid regulating properties, as well as a lower toxicity in comparison with known preparations.

  新的化合物，是9-氨基蒽醌的衍生物，其通式为(I)，其中R = H、CH₃；R¹ = H、CH₃、Br；R² = H、CH₃；R³ = 烷基-C₁-C₅、芳基甲基、二乙氨基乙基；X = C = O、CHOH；Y = CH₂；X + Y = CH = CH；以及它们与有机和非有机酸的盐。所需化合物是通过将替代的蒽酰胺基酸腈与二甲酮反应，随后将中间体烯胺腈环化成相应的9-氨基蒽醌酮，还原后得到它们及其衍生物烷基化或芳基烷基化的相应醇，水合后得到9-氨基-3,4-二氢蒽醌。在动物实验中，所述9-氨基蒽醌的衍生物表现出精神药理、抗遗忘和调脂作用，并且与已知制剂相比毒性更低。
• US5672707A
  申请人：——

  公开号：US5672707A

  公开（公告）日：1997-09-30