(3R)-4-methyl-3-(methylamino)pentan-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R)-4-methyl-3-(methylamino)pentan-2-one
• 化学式: C₇H₁₅NO
• 分子量: 129.2
• InChiKey: IGDRULGCCDGCAF-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS
  申请人：Guichard Gilles

  公开号：US20100183642A1

  公开（公告）日：2010-07-22

  The invention concerns a compound of formula (I), wherein Y represents a macrocycle whereof the cycle comprises 9 to 36 atoms, and is functionalized by three amine or COOH functions; R c represents a group of formula H—X a —X b —X c —X d —X e —(X f ) i —, wherein i represents 0 or 1, X n is in particular selected among lysine, arginine, ornithine residues, X b is in particular selected among glycine, asparagine, L-proline or D-proline residues, X c et X d are in particular selected among tyrosine, phenylalanine or 3-nitrotyrosine residues, X e et X f are in particular selected among the following amino acid residues: NH 2 —(CH 2 ) n —COOH, n ranging from 1 to 10 or NH 2 —(CH 2 —CH 2 —O) m —CH 2 CH 2 COOH, m ranging from 3 to 6, provided that one at least of the amino acid residues X a , X b , X c and X d is different from the corresponding amino acid in the sequence of the natural CD40 143 Lys-Gly-Tyr-Tyr 146 fragment

  该发明涉及一种化合物，其化学式为（I），其中Y代表一个大环，该环包含9至36个原子，并且通过三个胺基或COOH功能官能化；Rc代表一个化学式为H—Xa—Xb—Xc—Xd—Xe—（Xf）i—的基团，其中i代表0或1，Xn特别选自赖氨酸、精氨酸、鸟氨酸残基之一，Xb特别选自甘氨酸、天冬氨酸、L-脯氨酸或D-脯氨酸残基之一，Xc和Xd特别选自酪氨酸、苯丙氨酸或3-硝基酪氨酸残基之一，Xe和Xf特别选自以下氨基酸残基之一：NH2—（CH2）n—COOH，其中n取1至10之间的值，或NH2—（ — —O）m— COOH，其中m取3至6之间的值，前提是氨基酸残基Xa、Xb、Xc和Xd中至少有一个与天然CD40143Lys-Gly-Tyr-Tyr146片段中相应的氨基酸不同。
• METHODS FOR THE USE OF INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES
  申请人：Olson Gary Lee

  公开号：US20090111755A1

  公开（公告）日：2009-04-30

  The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.

  本发明涉及化合物、含有这些化合物的药物组合物以及它们的使用方法。特别地，本发明的化合物对于治疗或预防与T细胞增殖相关的疾病，如自身免疫性疾病和紊乱，是有用的。
• INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES
  申请人：Olson Gary Lee

  公开号：US20120252734A1

  公开（公告）日：2012-10-04

  The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.

  本发明涉及化合物、含有这种化合物的制药组合物以及它们的使用方法。特别地，本发明的化合物对于治疗或预防与T细胞增殖相关的疾病，如自身免疫性疾病和紊乱，是有用的。
• US7439231B2
  申请人：——

  公开号：US7439231B2

  公开（公告）日：2008-10-21
• US8222215B2
  申请人：——

  公开号：US8222215B2

  公开（公告）日：2012-07-17