(2E)-2-cyano-3-[4-(1-phenylethoxy)phenyl]prop-2-enamide | 6195-43-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2E)-2-cyano-3-[4-(1-phenylethoxy)phenyl]prop-2-enamide
• 英文别名: (E)-2-cyano-3-[4-(1-phenylethoxy)phenyl]prop-2-enamide
• CAS: 6195-43-3
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.3
• InChiKey: UZSGIZCWHXWZRA-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS
  申请人：The Scripps Research Institute

  公开号：US20220204485A1

  公开（公告）日：2022-06-30

  In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.