cyclopropyl cyclopentyl ketone | 58774-11-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cyclopropyl cyclopentyl ketone
• 英文别名: cyclopentyl-cyclopropyl-methanone；Methanone, cyclopentylcyclopropyl-；cyclopentyl(cyclopropyl)methanone
• CAS: 58774-11-1
• 化学式: C₉H₁₄O
• 分子量: 138.21
• InChiKey: YXFMOQKVIGBGML-UHFFFAOYSA-N

物化性质

• 沸点：
  201.4±8.0 °C(Predicted)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-溴嘧啶 、 cyclopropyl cyclopentyl ketone 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以65%的产率得到Cyclopentyl-cyclopropyl-pyrimidin-5-yl-methanol
  参考文献：
  名称：

  Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines

  摘要：

  The inhibition of estrogen biosynthesis has been suggested to be an effective treatment of hormone-dependent diseases, particularly breast cancer. Several series of 5-substituted pyrimidine derivatives have been synthesized and tested for their ability to inhibit the enzyme aromatase (estrogen synthetase). Compounds were evaluated in an in vitro assay that measured the inhibition of rat ovarian microsomal aromatase activity. Greatest inhibitory activity was achieved in the cases of diarylpyrimidinemethanols and diarylpyrimidinyl methanes which were substituted in the 4- and 4'-positions with electron-withdrawing substituents, particularly Cl.

  DOI：

  10.1021/jm00391a016

文献信息

• Enamines—XXXIX
  作者：D. Pocar、R. Stradi、P. Trimarco

  DOI：10.1016/0040-4020(75)80248-1

  日期：1975.1

  The enamines from cyclopropyl-methyl-, -ethyl- and -cyclopentylketone have been prepared by reaction of the ketone with a secondary amine and TiCl4. Their vinylcyclopropane structure has been demonstrated by NMR. The reaction of dicyclopropylketone, cyclopropylphenylketone or cyclopropyl-α-thienylketone with secondary amines and TiCl4 afforded homoallylic rearrangement products, namely 1-cyclopropyl-

  环丙基-甲基-，-乙基-和-环戊基酮的烯胺是通过酮与仲胺和TiCl 4反应制备的。它们的乙烯基环丙烷结构已通过NMR证实。二环丙基酮，环丙基苯基酮或环丙基-α-噻吩基酮与仲胺和TiCl 4的反应提供了均烯丙基重排产物，即1-环丙基-，1-苯基-和1-（α-噻吩基）-1,4-二氨基-1-丁烯。
• Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
  申请人：G.D. Searle & Co.

  公开号：US20010018446A1

  公开（公告）日：2001-08-30

  The invention relates to substituted N-Aliphatic-N-Aromatic tertiary - Heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis, dyslipidemia, and other coronary artery disease.

  该发明涉及替代N-脂肪基-N-芳香族三级-杂原子烷胺化合物，可用作胆固醇酯转移蛋白（CETP；血浆脂质转移蛋白-I）的抑制剂，以及治疗动脉粥样硬化、血脂异常和其他冠状动脉疾病的化合物、组合物和方法。
• [EN] 4-(3,3-DIHALO-ALLYLOXY)PHENOXY ALKYL DERIVATIVES<br/>[FR] DERIVES 4-(3,3-DIHALO-ALLYLOXY)PHENOXYALKYLE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2004002943A1

  公开（公告）日：2004-01-08

  Compounds of formula (I), wherein A1, A2 and A3 are each independently of the others a bond or a C1-C6alkylene bridge; A4 is a C1-C6alkylene bridge; Di s CH or N; W is, for example, O, NR7 or S; T is, for example, a bond, O, NH or NR7; Q is O, NR7, S, SO or SO2; Y is O, NR7, S, SO, or SO2; X1 and X2 are each independently of the other fluorine, chlorine or bromine; R1, R2 and R3 ar, for example, H, halogen, CN, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylcarbonyl or C2-C6alkenyl; R4 is, for example, H, halogen, CN, nitro or C1-C6alkyl; R5 and R6 are, for example, H, CN, OH, C1-C6alkyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C6alkyl, C1-C6 haloalky, C1-C6alkoxy or C1-C6haloalkoxy; R7 is H, C1-C6alkyl, C1-C6alkoxyalkyl or C1-C6alkylcarbonyl; k, when D is nitrogen, is 1, 2 or 3; or, when D is CH, is 1, 2, 3 or 4; and m is 1 or 2; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in free form or in salt form, a process for the preparation of those compounds and their use, pesticidal compositions in which the active ingredient has been selected from those compounds or an agrochemically acceptable salt thereof, a process for the preparation of those compositions and their use, plant propagation material treated with those compositions, and a method of controlling pests.

  化学式为（I）的化合物，其中A1、A2和A3各自独立地为键或C1-C6烷基桥；A4为C1-C6烷基桥；Di为CH或N；W为例如O、NR7或S；T为例如键、O、NH或NR7；Q为O、NR7、S、SO或SO2；Y为O、NR7、S、SO或SO2；X1和X2各自独立地为氟、氯或溴；R1、R2和R3例如为H、卤素、CN、硝基、C1-C6烷基、C1-C6卤代烷基、C1-C6烷基羰基或C2-C6烯基；R4例如为H、卤素、CN、硝基或C1-C6烷基；R5和R6例如为H、CN、OH、C1-C6烷基、C3-C8环烷基、C3-C8环烷基-C1-C6烷基、C1-C6卤代烷氧基或C1-C6烷氧基；R7为H、C1-C6烷基、C1-C6烷氧基烷基或C1-C6烷基羰基；当D为氮时，k为1、2或3；或当D为CH时，k为1、2、3或4；m为1或2；适用时，它们的可能的E/Z异构体、E/Z异构体混合物和/或互变异构体，均为自由形式或盐形式，制备这些化合物的方法及其用途，所述活性成分被选自这些化合物或其农药学上可接受的盐的杀虫剂组合物，制备这些组合物的方法及其用途，用这些组合物处理的植物繁殖材料，以及控制害虫的方法。
• TAYLOR, H. M.;JONES, C. D.;DAVENPORT, J. D.;HIRSCH, K. S.;KRESS, T. J.;WE+, J. MED. CHEM., 30,(1987) N 8, 1359-1365
  作者：TAYLOR, H. M.、JONES, C. D.、DAVENPORT, J. D.、HIRSCH, K. S.、KRESS, T. J.、WE+

  DOI：——

  日期：——
• 4-(3,3-DIHALO-ALLYLOXY)PHENOXY ALKYL DERIVATIVES
  申请人：Syngenta Participations AG

  公开号：EP1517881A1

  公开（公告）日：2005-03-30