(4S)-4-(2-methoxyphenyl)-3,7,7-trimethyl-2,4,6,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (4S)-4-(2-methoxyphenyl)-3,7,7-trimethyl-2,4,6,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-5-one
• 化学式: C₂₀H₂₃N₃O₂
• 分子量: 337.4
• InChiKey: KYFJPYWXCUCRPE-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  67
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• KINASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Wagner Florence Fevrier

  公开号：US20140107141A1

  公开（公告）日：2014-04-17

  The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer.

  本发明提供了I式化合物，其药学上可接受的盐和药物组合物。本发明的化合物有用于抑制激酶（例如GSK3（例如GSK3α或GSK3β）或CK1）活性。本发明还提供了使用本文所述化合物治疗激酶介导的疾病的方法，例如神经系统疾病、精神障碍、代谢性疾病和癌症。
• Kinase inhibitors and methods of use thereof
  申请人：The Broad Institute, Inc.

  公开号：US11052080B2

  公开（公告）日：2021-07-06

  The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

  本发明提供了式 I 的化合物、其药学上可接受的盐及其药物组合物。本发明化合物可用于抑制激酶（如 GSK3（如 GSK3α 或 GSK3β）或 CK1）活性。本发明进一步提供了使用本文所述化合物治疗激酶介导的疾病，如神经系统疾病、精神疾病、代谢紊乱和癌症的方法。
• US9096594B2
  申请人：——

  公开号：US9096594B2

  公开（公告）日：2015-08-04
• [EN] GSK3 INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE GSK3 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BROAD INST INC

  公开号：WO2014059383A1

  公开（公告）日：2014-04-17

  The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3a or GSK3P) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer. I