3-(3-Chloro-4-{[5-(trifluoromethyl)-2-pyridinyl]oxy}anilino)-3-oxopropanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(3-Chloro-4-{[5-(trifluoromethyl)-2-pyridinyl]oxy}anilino)-3-oxopropanoic acid
• 英文别名: 3-[3-chloro-4-[5-(trifluoromethyl)pyridin-2-yl]oxyanilino]-3-oxopropanoic acid
• 化学式: C₁₅H₁₀ClF₃N₂O₄
• 分子量: 374.7
• InChiKey: AQOIAODAHOWPFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Selective high-affinity polydentate ligands and methods of making such
  申请人：LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

  公开号：US10292992B2

  公开（公告）日：2019-05-21

  This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

  本发明提供了新型多齿选择性高亲和性配体（SHALs），可以以类似于使用抗体的方式用于各种应用。SHALs 通常由多个配体组成，每个配体与目标分子的不同区域结合。配体直接连接或通过连接体连接，从而形成多齿分子，通常能以高选择性和高热敏性结合目标分子。
• SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP2268654B1

  公开（公告）日：2017-01-25
• US9884070B2
  申请人：——

  公开号：US9884070B2

  公开（公告）日：2018-02-06
• [EN] SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH<br/>[FR] LIGANDS POLYDENTÉS SÉLECTIFS À HAUTE AFFINITÉ ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：UNIV CALIFORNIA

  公开号：WO2009132020A2

  公开（公告）日：2009-10-29

  This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.