1-(3-Chloro-2-thienyl)-3-(dimethylamino)-2-propen-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-Chloro-2-thienyl)-3-(dimethylamino)-2-propen-1-one
• 英文别名: (E)-1-(3-chlorothiophen-2-yl)-3-(dimethylamino)prop-2-en-1-one
• 化学式: C₉H₁₀ClNOS
• 分子量: 215.7
• InChiKey: JDJRLADAALOSDU-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  48.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying And Using The Same
  申请人：Huang Qihong

  公开号：US20120010177A1

  公开（公告）日：2012-01-12

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying and Using the Same
  申请人：Huang Qihong

  公开号：US20130023498A1

  公开（公告）日：2013-01-24

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• US20140255386A1
  申请人：——

  公开号：US20140255386A1

  公开（公告）日：2014-09-11
• [EN] PYRAZOLE FUNGICIDES 3-SUBSTITUTED BY A HETEROCYCLIC RING<br/>[FR] FONGICIDES PYRAZOLES SUBSTITUES EN POSITION 3 PAR UN HETEROCYCLE
  申请人：RHONE POULENC AGROCHIMIE

  公开号：WO1994029300A1

  公开（公告）日：1994-12-22

  (EN) Pyrazoles 3-substituted by a heterocyclic ring. These pyrazoles are of formulae (I) and (Ibis) wherein Het = an optionally substituted heterocyclic ring; Y1, Y2 = hal, nitro, CN, alkyl, alkoxy, acyl; Z = H, nitro, CN, (halo)alkyl, alkylS(O)n, wherein n = 1 or 2, optionally substitued aminoalkyl, acyl, aminocarbonyl, alkoxycarbonyl. Fungicides for agricultural use.(FR) Pyrazoles substitués en position 3 par un hétérocycle. Ils sont de formule (I) et (Ibis) avec Het: hétérocycle pouvant être substitué; Y1, Y2: H, hal, nitro, CN, alkyle, alkoxy, acyle; Z: H, nitro, CN, (halo)alkyle, alkylS(O)n avec n = 1 ou 2, aminoalkyle evt substitué, acyle, aminocarbonyle, alcoxycarbonyle. Fongicides pour l'agriculture.