N-(4-methoxyphenyl)-2-(4-methylphenyl)quinolin-4-amine | 1246760-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(4-methoxyphenyl)-2-(4-methylphenyl)quinolin-4-amine
• CAS: 1246760-56-4
• 化学式: C₂₃H₂₀N₂O
• 分子量: 340.425
• InChiKey: KRQYLPOYWMGHNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chloro-2-(4-methyl)phenyl quinoline 、 甲氧苯胺 在 四氯化锡 作用下， 反应 4.0h， 生成 N-(4-methoxyphenyl)-2-(4-methylphenyl)quinolin-4-amine
  参考文献：
  名称：

  Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities

  摘要：

  A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.043