Trichomonacid | 7195-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Trichomonacid
• 英文别名: 1-N,1-N-diethyl-4-N-[6-methoxy-2-[(E)-2-(4-nitrophenyl)ethenyl]quinolin-4-yl]pentane-1,4-diamine
• CAS: 7195-14-4
• 化学式: C27H34N4O3
• 分子量: 462.6
• InChiKey: XWBADQOPXPRKBX-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  83.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] ANTIMALARIAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIPALUDIQUES
  申请人：UNIV CENTRAL FLORIDA RES FOUND INC

  公开号：WO2020206252A1

  公开（公告）日：2020-10-08

  Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; R1 is a moiety comprising a secondary amine and a tertiary amine joined by a C2 to C4 alkyl chain; and R2 is CF3, F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds.

  抗疟疾化合物的公式为：其中n为1或2；X为C或N；R1是由C2到C4的烷基链连接的次级胺和三级胺组成的基团；R2为CF3、F或H，或其类似物、组合物、衍生物、前药、立体异构体或药用可接受的盐。包括抗疟疾化合物的药用化合物。治疗或预防疟疾的方法包括给予有效量的抗疟疾化合物。
• ANTIMALARIAL COMPOUNDS
  申请人：UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US20220204452A1

  公开（公告）日：2022-06-30

  Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; R 1 is a moiety comprising a secondary amine and a tertiary amine joined by a C 2 to C 4 alkyl chain; and R 2 is CF 3 , F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds.