1-{4-[3-(4-ccetylphenyl)cinnolin-4-yl]phenyl}ethan-1-one | 1313886-29-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-{4-[3-(4-ccetylphenyl)cinnolin-4-yl]phenyl}ethan-1-one
• 英文别名: 1-[4-[3-(4-Acetylphenyl)cinnolin-4-yl]phenyl]ethanone
• CAS: 1313886-29-1
• 化学式: C₂₄H₁₈N₂O₂
• 分子量: 366.419
• InChiKey: CUYYIBVSAOKGCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,1'-[ethyne-1,2-diylbis(4,1-phenylene)]diethanone 、 1-(2-iodophenyl)-3,3-diethyltriazene 在 三正丁胺 、 三(邻甲基苯基)磷 、 palladium dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以82%的产率得到1-{4-[3-(4-ccetylphenyl)cinnolin-4-yl]phenyl}ethan-1-one
  参考文献：
  名称：

  Synthesis of 3,4-disubstituted cinnolines by the Pd-catalyzed annulation of 2-iodophenyltriazenes with an internal alkyne

  摘要：

  A simple and efficient synthesis of cinnolines was achieved by a palladium-catalyzed annulation methodology. 3,4-Disubstituted cinnolines are prepared via palladium-catalyzed annulation of 2-iodophenyltriazenes with an internal alkyne in moderate to good yields. Several internal alkynes are applicable to this reaction and it is compatible with a number of functional groups. (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2011.04.079

文献信息

• Synthesis of 3,4-disubstituted cinnolines by the Pd-catalyzed annulation of 2-iodophenyltriazenes with an internal alkyne
  作者：Chuan Zhu、Motoki Yamane

  DOI：10.1016/j.tet.2011.04.079

  日期：2011.7

  A simple and efficient synthesis of cinnolines was achieved by a palladium-catalyzed annulation methodology. 3,4-Disubstituted cinnolines are prepared via palladium-catalyzed annulation of 2-iodophenyltriazenes with an internal alkyne in moderate to good yields. Several internal alkynes are applicable to this reaction and it is compatible with a number of functional groups. (C) 2011 Published by Elsevier Ltd.