methyl (Z)-3-(4-chlorophenyl)-2-(trimethylgermylmethyl)prop-2-enoate | 847374-22-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl (Z)-3-(4-chlorophenyl)-2-(trimethylgermylmethyl)prop-2-enoate
• CAS: 847374-22-5
• 化学式: C₁₄H₁₉ClGeO₂
• 分子量: 327.347
• InChiKey: CBGIRVWQAYSIMF-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Hexamethyldigermane 、 methyl 3-acetoxy-3-(4-chlorophenyl)-2-methylenepropanoate 在 tris(dibenzylideneacetone)dipalladium (0) 作用下， 以 甲苯 为溶剂， 生成 methyl (E)-3-(4-chlorophenyl)-2-(trimethylgermylmethyl)prop-2-enoate 、 methyl (Z)-3-(4-chlorophenyl)-2-(trimethylgermylmethyl)prop-2-enoate
  参考文献：
  名称：

  Palladium-Catalyzed Regio- and Stereoselective Cross-Coupling of Baylis-Hillman Adducts and Bimetals:  A Novel Method for the Synthesis of Substituted Allylsilanes and Allylgermanes

  摘要：

  Cross-coupling reactions between Baylis-Hillman acetate adducts and bimetallic reagents (Si-Si, Ge-Ge) catalyzed by a phosphine-free palladium complex are described. 3-Substituted-2-carbonylallylsilanes and allylgermanes were isolated in high yields. The cross-coupling reactions are regio- and stereoselective.

  DOI：

  10.1021/om0492451

文献信息

• Palladium-Catalyzed Regio- and Stereoselective Cross-Coupling of Baylis-Hillman Adducts and Bimetals:  A Novel Method for the Synthesis of Substituted Allylsilanes and Allylgermanes
  作者：George W. Kabalka、Bollu Venkataiah、Gang Dong

  DOI：10.1021/om0492451

  日期：2005.2.1

  Cross-coupling reactions between Baylis-Hillman acetate adducts and bimetallic reagents (Si-Si, Ge-Ge) catalyzed by a phosphine-free palladium complex are described. 3-Substituted-2-carbonylallylsilanes and allylgermanes were isolated in high yields. The cross-coupling reactions are regio- and stereoselective.