(Z)-3-phenyl-N-(2-pyridin-3-yl-1,3-benzoxazol-5-yl)prop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (Z)-3-phenyl-N-(2-pyridin-3-yl-1,3-benzoxazol-5-yl)prop-2-enamide
• 化学式: C₂₁H₁₅N₃O₂
• 分子量: 341.4
• InChiKey: AJIYEOABHGCCAA-FLIBITNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Small molecule IRE1-α inhibitors
  申请人：Cornell University

  公开号：US10125123B2

  公开（公告）日：2018-11-13

  Described herein are IRE1α inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.

  本文描述了 IRE1α 抑制剂、含有此类抑制剂的组合物以及包括施用此类化合物的治疗方法。本申请全文提供了示例化合物。
• SMALL MOLECULE IRE1-ALPHA INHIBITORS
  申请人：Cornell University

  公开号：US20170253590A1

  公开（公告）日：2017-09-07

  Described herein are IRE1α inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.
• METHODS FOR CONTROLLING PROSTAGLANDIN-MEDIATED BIOLOGICAL PROCESSES
  申请人：Cornell University

  公开号：US20220160705A1

  公开（公告）日：2022-05-26

  Described herein are compositions and methods for reducing prostaglandin production and pain in a mammalian or avian subject. Such compositions and methods inhibit reduce prostaglandinendoperoxide synthase 2 (Ptgs2/Cox-2) and prostaglandin E synthase (Ptges/mPGES-1) activities in the subject, but do not substantially inhibit prostaglandin-endoperoxide synthase 1 (Cox1) or prostaglandin E synthase 2 activities in the subject.