(Z)-4,5-dichloro-pent-3-en-2-one | 54813-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-4,5-dichloro-pent-3-en-2-one
• 英文别名: (Z)-4,5-dichloropent-3-en-2-one
• CAS: 54813-96-6
• 化学式: C₅H₆Cl₂O
• 分子量: 153.008
• InChiKey: CSMXOLOYALRKEU-DJWKRKHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (Z)-4,5-dichloro-pent-3-en-2-one 在 盐酸羟胺 作用下， 以 甲醇 为溶剂， 生成 5-氯甲基-3-甲基异噁唑
  参考文献：
  名称：

  Synthesis of 3-alkyl(cycloalkyl, aryl)-5-chloromethylisoxazoles

  摘要：

  DOI：

  10.1007/bf00472468
• 作为产物：
  描述：

  3-氯丙炔 、 乙酰氯 生成 (Z)-4,5-dichloro-pent-3-en-2-one
  参考文献：
  名称：

  Martin,G.J.; Kirschleger,B., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1974, vol. 279, p. 363 - 365

  摘要：

  DOI：

文献信息

• Dispenser with movable matrix comprising a plurality of tiny pills
  申请人：ALZA CORPORATION

  公开号：EP0300623A2

  公开（公告）日：1989-01-25

  A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.

  本发明公开了一种向使用环境输送小药丸的分配器。分配器包括一个环绕内部空间的壁，该内部空间包括分配器中的第一装置，用于在离开分配器时从分配器状态变为使用环境状态；第一装置中的小药丸；以及分配器中的第二装置，用于帮助分配器移位第一装置。
• Plurality of tiny pills in liquid dosage form
  申请人：ALZA CORPORATION

  公开号：EP0313992A1

  公开（公告）日：1989-05-03

  A delivery system is disclosed for delivering a beneficial agent to an environment of use. The delivery system comprises a plurality of tiny dosage forms comprising a beneficial agent. The delivery system also comprises means for maintaining (a) the physical and chemical integrity of the dosage forms and for (b) inhibiting delivery of the beneficial agent during non-performance of the delivery system.

  本发明公开了一种输送系统，用于向使用环境输送有益制剂。该给药系统包括多种微小剂型，其中包含一种有益药剂。递送系统还包括用于保持（a）剂型的物理和化学完整性和（b）在递送系统不工作期间抑制有益药剂递送的装置。
• Oral pharmaceutical dosage forms
  申请人：Durect Corporation

  公开号：US10328068B2

  公开（公告）日：2019-06-25

  Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable for administration of methylphenidate are also provided. Methods of treating ADD and ADHD using the oral dosage forms are also provided.

  提供了适合服用哌醋甲酯的控释口服剂型。还提供了适合服用哌醋甲酯的抗滥用控释口服剂型。还提供了使用口服剂型治疗注意力缺失症和多动症的方法。
• Oral Pharmaceutical Dosage Forms
  申请人：Durect Corporation

  公开号：US20160058746A1

  公开（公告）日：2016-03-03

  Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable for administration of methylphenidate are also provided. Methods of treating ADD and ADHD using the oral dosage forms are also provided.
• ORAL PHARMACEUTICAL DOSAGE FORMS
  申请人：Durect Corporation

  公开号：US20180214435A1

  公开（公告）日：2018-08-02

  Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable for administration of methylphenidate are also provided. Methods of treating ADD and ADHD using the oral dosage forms are also provided.