3-[5-Amino-2-[2-[2-methyl-4-[2-(2-propoxyethoxy)ethoxy]phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-[5-Amino-2-[2-[2-methyl-4-[2-(2-propoxyethoxy)ethoxy]phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid
• 英文别名: 3-[5-amino-2-[2-[2-methyl-4-[2-(2-propoxyethoxy)ethoxy]phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid
• 化学式: C₃₁H₃₇N₃O₅
• 分子量: 531.6
• InChiKey: IKSATTSMLPQMCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  39
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] STABILISED PROTEINS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS<br/>[FR] PROTÉINES STABILISÉES POUR L'IMMUNISATION CONTRE LE STAPHYLOCOQUE DORÉ
  申请人：NOVARTIS AG

  公开号：WO2014033191A1

  公开（公告）日：2014-03-06

  Elimination of disulphide bond formation of cysteine-containing S.aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S.aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
• [EN] IMMUNISING AGAINST STAPHYLOCOCCAL BONE AND JOINT INFECTIONS<br/>[FR] IMMUNISATION CONTRE LES INFECTIONS STAPHYLOCOCCIQUES DES OS ET DES ARTICULATIONS
  申请人：GAXOSMITHKLINE BIOLOG SA

  公开号：WO2015140108A1

  公开（公告）日：2015-09-24

  Immunisation with EsxA, EsxB, FhuD2, Sta011, and/or Hla leads to significantly lower bacterial burden in joints of animals who are exposed to S.aureus infections. Thus the invention provides an effective way of preventing and/or treating S.aureus infections of bones and joints, thereby avoiding disorders such as osteomyelitis, septic arthritis, and prosthetic joint infection.
• [EN] MUTANT STAPHYLOCOCCAL ANTIGENS<br/>[FR] ANTIGÈNES STAPHYLOCOCCIQUES MUTANTS
  申请人：GLAXOSMITHKLINE BIOLOG SA

  公开号：WO2015144653A1

  公开（公告）日：2015-10-01

  Mutant SpA with decreased affinity for the Fcγ portion of human IgG is provided. Immunisation with EsxA, EsxB, FhuD2, Sta011, Hla and said mutant SpA provides striking results in a renal abscess model of S.aureus infection.
• [EN] IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS<br/>[FR] IMMUNISATION CONTRE STAPHYLOCOCCUS AUREUS
  申请人：GLAXOSMITHKLINE BIOLOG SA

  公开号：WO2015144655A1

  公开（公告）日：2015-10-01

  Immunisation with EsxA, EsxB, FhuD 2, Sta011, Hla and a mutant SpA provides striking results in a renal abscess model of S.aureus infection. The mutant SpA has decreased affinity for the Fcy portion of human IgG and for the Fab portion of VH3-containing B cell receptors.