1-O-tert-butyl 7-O-phenyl 8-butoxy-4-(dimethylamino)-5-fluoro-6-methyl-3,4-dihydro-2H-quinoline-1,7-dicarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-O-tert-butyl 7-O-phenyl 8-butoxy-4-(dimethylamino)-5-fluoro-6-methyl-3,4-dihydro-2H-quinoline-1,7-dicarboxylate
• 化学式: C₂₈H₃₇FN₂O₅
• 分子量: 500.6
• InChiKey: QVDHALVEWSDFJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

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  申请人：Tetraphase Pharmaceuticals, Inc.

  公开号：US20160107988A1

  公开（公告）日：2016-04-21

  The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
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  申请人：Tetraphase Pharmaceuticals, Inc.

  公开号：US20170305852A1

  公开（公告）日：2017-10-26

  The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
• US9573895B2
  申请人：——

  公开号：US9573895B2

  公开（公告）日：2017-02-21
• [EN] TETRACYCLINE COMPOUNDS<br/>[FR] COMPOSÉS DE TÉTRACYCLINES
  申请人：TETRAPHASE PHARMACEUTICALS INC

  公开号：WO2014036502A2

  公开（公告）日：2014-03-06

  The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.