(Z)-3-pyridin-4-yl-2-quinolin-4-ylprop-2-enenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (Z)-3-pyridin-4-yl-2-quinolin-4-ylprop-2-enenitrile
• 化学式: C₁₇H₁₁N₃
• 分子量: 257.29
• InChiKey: TTYTZSYNAWYOSZ-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples
  申请人：BECTON DICKINSON AND COMPANY

  公开号：US10962533B2

  公开（公告）日：2021-03-30

  Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

  本文提供了用于检测和/或识别培养样本中一种或多种特定微生物的方法、系统和设备。指示剂颗粒，如表面增强拉曼光谱（SERS）活性纳米颗粒，每个都有一个或多个与一个或多个相关微生物具有亲和力的特异性结合构件，可与培养样本中的特异性微生物形成复合物。此外，搅拌磁性捕获颗粒也与一种或多种对一种或多种相关微生物具有亲和力的特异性结合构件相关联，可用于捕获微生物-指示剂颗粒复合物，并将复合物集中在检测容器的局部区域，以便随后进行检测和鉴定。复合物可以被分散、造粒和再分散，以便在培养过程中对培养样本进行多次再检测，从而实现对培养样本的实时监测。
• METHODS, SYSTEMS, AND DEVICES FOR DETECTING AND IDENTIFYING MICROORGANISMS IN MICROBIOLOGICAL CULTURE SAMPLES
  申请人：Becton Dickinson and Company

  公开号：EP2836835A2

  公开（公告）日：2015-02-18
• SERS NANOPARTICLES AND METHODS FOR USING THE SAME
  申请人：BECTON, DICKINSON AND COMPANY

  公开号：US20160327551A1

  公开（公告）日：2016-11-10

  Provided are SERS nanoparticles. In certain aspects, the SERS nanoparticles are fluorescently labeled SERS nanoparticles that include a SERS nanoparticle and a fluorescent label stably associated with a surface of the SERS nanoparticle. Aspects of the present disclosure further include methods of using the SERS nanoparticles, e.g., in a variety of different applications, as well as kits that find use in practicing embodiments of the methods.
• US9874555B2
  申请人：——

  公开号：US9874555B2

  公开（公告）日：2018-01-23
• [EN] METHODS, SYSTEMS, AND DEVICES FOR DETECTING AND IDENTIFYING MICROORGANISMS IN MICROBIOLOGICAL CULTURE SAMPLES<br/>[FR] PROCÉDÉS, SYSTÈMES, ET DISPOSITIFS POUR DÉTECTER ET IDENTIFIER DES MICRO-ORGANISMES DANS DES ÉCHANTILLONS DE CULTURE MICROBIOLOGIQUES
  申请人：BECTON DICKINSON CO

  公开号：WO2013165615A2

  公开（公告）日：2013-11-07

  Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.