10,11-dimethyl-8,12-dihydrobenzo[5,6]chromeno[4,3-b]pyrrolo[3,2-f]quinoline | 1333397-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10,11-dimethyl-8,12-dihydrobenzo[5,6]chromeno[4,3-b]pyrrolo[3,2-f]quinoline
• 英文别名: 18,19-Dimethyl-12-oxa-20,25-diazahexacyclo[12.11.0.02,11.03,8.016,24.017,21]pentacosa-1(25),2(11),3,5,7,9,14,16(24),17(21),18,22-undecaene；18,19-dimethyl-12-oxa-20,25-diazahexacyclo[12.11.0.02,11.03,8.016,24.017,21]pentacosa-1(25),2(11),3,5,7,9,14,16(24),17(21),18,22-undecaene
• CAS: 1333397-64-0
• 化学式: C₂₄H₁₈N₂O
• 分子量: 350.42
• InChiKey: WUZRQWWFOSSFHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,3-二甲基-1H-吲哚-5-胺 、 2-(2-丙炔氧基)-1-萘醛 在 copper(l) iodide 作用下， 反应 3.0h， 以85%的产率得到10,11-dimethyl-8,12-dihydrobenzo[5,6]chromeno[4,3-b]pyrrolo[3,2-f]quinoline
  参考文献：
  名称：

  Synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines via intramolecular aza Diels–Alder reaction

  摘要：

  An efficient and convenient one-pot intramolecular aza Diels-Alder approach for the synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines has been reported. Particularly valuable features of this methodology include simple execution, inexpensive catalyst, and good product yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.033

文献信息

• Synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines via intramolecular aza Diels–Alder reaction
  作者：Subburethinam Ramesh、Rajagopal Nagarajan

  DOI：10.1016/j.tetlet.2011.07.033

  日期：2011.9

  An efficient and convenient one-pot intramolecular aza Diels-Alder approach for the synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines has been reported. Particularly valuable features of this methodology include simple execution, inexpensive catalyst, and good product yields. (C) 2011 Elsevier Ltd. All rights reserved.