(6-Phenyl-5,6,7,8-tetrahydroquinolin-8-yl)carbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (6-Phenyl-5,6,7,8-tetrahydroquinolin-8-yl)carbamic acid
• 英文别名: (6-phenyl-5,6,7,8-tetrahydroquinolin-8-yl)carbamic acid
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.31
• InChiKey: RBNSDALREKPJAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PYRIDINE CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR DE CGRP À BASE DE PYRIDINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013169563A1

  公开（公告）日：2013-11-14

  The present invention is directed to pyridine derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及吡啶衍生物，其为CGRP受体拮抗剂，在治疗或预防涉及CGRP的疾病，如偏头痛等方面有用。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及CGRP的这类疾病中使用这些化合物和组合物。
• PYRIDINE CGRP RECEPTOR ANTAGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150099771A1

  公开（公告）日：2015-04-09

  The present invention is directed to pyridine derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及吡啶衍生物，其为CGRP受体拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如偏头痛。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物预防或治疗涉及CGRP的这些疾病的方法。
• US9227973B2
  申请人：——

  公开号：US9227973B2

  公开（公告）日：2016-01-05