4,5,6,7-Tetrafluoro-1-oxaspiro<2.4>hepta-4,6-diene | 131152-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 4,5,6,7-Tetrafluoro-1-oxaspiro<2.4>hepta-4,6-diene
• 英文别名: 4,5,6,7-Tetrafluoro-1-oxaspiro[2.4]hepta-4,6-diene
• CAS: 131152-59-5
• 化学式: C₆H₂F₄O
• 分子量: 166.075
• InChiKey: XTCZUIHXZGMNGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,5,6,7-Tetrafluoro-1-oxaspiro<2.4>hepta-4,6-diene 、 4-苯基-1,2,4-三唑啉-3,5-二酮 以 乙醚 为溶剂， 反应 0.08h， 生成 1,7,8,9-tetrafluoro-4-phenylspiro[2,4,6-triazatricyclo[5.2.1.02,6]dec-8-ene-10,2'-oxirane]-3,5-dione
  参考文献：
  名称：

  Carbonyl chemistry of tetrafluorocyclopentadienone

  摘要：

  In order to control the Diels-Alder reactivity of the very labile title compound 1, experiments designed to modify the carbonyl group have been carried out. With methanol a hemiketal (4) is formed reversibly at low temperatures, but conjugate addition to give 3-methoxy derivatives 5 and 6 occurs at ordinary temperatures. Diazomethane reacts with 1 in cold methanol to give a spirooxirane (9) which undergoes Diels-Alder dimerization orders of magnitude slower than dienone 1 at room temperature. Hydrogen cyanide gives a cyanohydrin (15) with 1 at low temperatures, but the compound decomposes at 0-degrees-C. Trimethylsilyl cyanide yields the trimethylsilyl cyanohydrin 16, a stable derivative of 1 that dimerizes only at elevated temperatures, yet retains reactivity as a Diels-Alder diene.

  DOI：

  10.1021/jo00001a032
• 作为产物：
  描述：

  tetrafluoro-cyclobut-3-ene-1,2-dicarboxylic acid anhydride 在 sodium methylate 作用下， 以 甲醇 、 乙醚 为溶剂， -78.0~585.0 ℃ 、133.32 Pa 条件下， 反应 4.0h， 生成 4,5,6,7-Tetrafluoro-1-oxaspiro<2.4>hepta-4,6-diene
  参考文献：
  名称：

  Carbonyl chemistry of tetrafluorocyclopentadienone

  摘要：

  In order to control the Diels-Alder reactivity of the very labile title compound 1, experiments designed to modify the carbonyl group have been carried out. With methanol a hemiketal (4) is formed reversibly at low temperatures, but conjugate addition to give 3-methoxy derivatives 5 and 6 occurs at ordinary temperatures. Diazomethane reacts with 1 in cold methanol to give a spirooxirane (9) which undergoes Diels-Alder dimerization orders of magnitude slower than dienone 1 at room temperature. Hydrogen cyanide gives a cyanohydrin (15) with 1 at low temperatures, but the compound decomposes at 0-degrees-C. Trimethylsilyl cyanide yields the trimethylsilyl cyanohydrin 16, a stable derivative of 1 that dimerizes only at elevated temperatures, yet retains reactivity as a Diels-Alder diene.

  DOI：

  10.1021/jo00001a032

文献信息

• LEMAL, DAVID M.;KLOPOTEK, DAVID L.;WILTERDINK, JANET L.;SAUNDERS, W. DANI+, J. ORG. CHEM., 56,(1991) N, C. 157-160
  作者：LEMAL, DAVID M.、KLOPOTEK, DAVID L.、WILTERDINK, JANET L.、SAUNDERS, W. DANI+

  DOI：——

  日期：——
• Carbonyl chemistry of tetrafluorocyclopentadienone
  作者：David M. Lemal、David L. Klopotek、Janet L. Wilterdink、W. Daniel Saunders

  DOI：10.1021/jo00001a032

  日期：1991.1

  In order to control the Diels-Alder reactivity of the very labile title compound 1, experiments designed to modify the carbonyl group have been carried out. With methanol a hemiketal (4) is formed reversibly at low temperatures, but conjugate addition to give 3-methoxy derivatives 5 and 6 occurs at ordinary temperatures. Diazomethane reacts with 1 in cold methanol to give a spirooxirane (9) which undergoes Diels-Alder dimerization orders of magnitude slower than dienone 1 at room temperature. Hydrogen cyanide gives a cyanohydrin (15) with 1 at low temperatures, but the compound decomposes at 0-degrees-C. Trimethylsilyl cyanide yields the trimethylsilyl cyanohydrin 16, a stable derivative of 1 that dimerizes only at elevated temperatures, yet retains reactivity as a Diels-Alder diene.