4-dipropylamino-butylaldehyde | 864913-21-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-dipropylamino-butylaldehyde
• 英文别名: 4-(dipropylamino)butanal
• CAS: 864913-21-3
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: SOWKYYLSDITOGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-dipropylamino-butylaldehyde 、 1,2,3,4-四氢异喹啉-6-甲腈 在 三乙酰氧基硼氢化钠 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 48.0h， 生成 2-(4-dipropylamino-butyl)-1,2,3,4-tetrahydro-isoquinolin-6-carbonitrile
  参考文献：
  名称：

  BASIC AMINE COMPOUND AND USE THEREOF

  摘要：

  公开号：

  EP1724263B1
• 作为产物：
  描述：

  (4,4-diethoxy-butyl)-dipropyl-amine 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 17.0h， 生成 4-dipropylamino-butylaldehyde
  参考文献：
  名称：

  BASIC AMINE COMPOUND AND USE THEREOF

  摘要：

  公开号：

  EP1724263B1

文献信息

• 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION
  申请人：Wakamoto Pharmaceutical Co., Ltd.

  公开号：EP1820799A1

  公开（公告）日：2007-08-22

  The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.

  本发明的目的是提供一种用化学式（1）表示的2,3,4,5-四氢-1H-1,5-苯二氮䓬衍生物，或其药学上可接受的盐，作为治疗和预防糖尿病、糖尿病肾病或肾小球硬化的药剂。
• [EN] COMPOUND CONTAINING BASIC GROUP AND USE THEREOF<br/>[FR] COMPOSÉ CONTENANT UN GROUPE BASIQUE ET UTILISATION
  申请人：ONO PHARMACEUTICAL CO

  公开号：WO2006022454A1

  公开（公告）日：2006-03-02

  A compound represented by the general formula (I-0): (I-0) (wherein the symbols are as defined in the description), a salt thereof, N-oxide form thereof, or solvate thereof, or a prodrug of any of these; and a medicinal use of these. The compound has CXCR4 antagonistic activity and is hence useful, e.g., as a preventive and/or therapeutic agent for CXCR4-mediated diseases, e.g., inflammatory/immunologic diseases (e.g., articular rheumatism, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions against transplanted organs), allergic diseases, infectious diseases (e.g., human immunodeficiency virus infection and acquired immunological deficiency syndrome), mental/nervous diseases, brain diseases, cardiac/vascular diseases, metabolic diseases, and carcinomatous diseases (e.g., cancers and cancer metastasis), or as an agent for regenerative medicine.

  一种由通式(I-0):(I-0)表示的化合物（其中符号如描述中所定义），其盐，N-氧化物形式，或溶剂合物，或这些的前药；以及这些的药用。该化合物具有CXCR4拮抗活性，因此可用作预防和/或治疗CXCR4介导的疾病，例如炎症/免疫疾病（例如关节风湿病，关节炎，视网膜病变，肺纤维化和对移植器官的排斥反应），过敏疾病，传染病（例如人类免疫缺陷病毒感染和获得性免疫缺陷综合症），精神/神经疾病，脑疾病，心脏/血管疾病，代谢疾病以及癌症疾病（例如癌症和癌症转移），或作为再生医学的药物。
• Compound Containing Basic Group and Use Thereof
  申请人：Kokubo Masaya

  公开号：US20080009495A1

  公开（公告）日：2008-01-10

  The present invention relates to a compound represented by formula (I-0): wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

  本发明涉及一种由式（I-0）表示的化合物：其中，式中的符号与本说明书中所述的意义相同，其盐，N-氧化物或溶剂化物或其前药，以及其医学用途。本发明的化合物具有对CXCR4的拮抗活性，因此可用作预防和/或治疗CXCR4介导的疾病的药物，例如，炎症和免疫性疾病（例如，类风湿性关节炎，关节炎，视网膜病变，肺纤维化，移植器官排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合症等），精神神经疾病，脑部疾病，心血管疾病，代谢性疾病和癌症性疾病（例如，癌症，癌症转移等），或作为再生疗法的药物。
• Amine-Based Compound and Use Thereof
  申请人：Saitou Atsushi

  公开号：US20070208007A1

  公开（公告）日：2007-09-06

  Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; typically, A 1 and A 2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): where X represents O, CH 2 , C(═O), NR 11 , or CHR 35 and D represents a group represented by the following formula (6): where Q represents a single bond, NR 12 , or a group represented by the formula (13): and Y represents a group represented by the following formula (7): where z represents a substitutable monocyclic or polycyclic aromatic ring; and B represents —NR 25 R 26 ; and R 1 to R 26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.

  以下是该段文本的中文翻译： 新型胺类化合物的化学式如下（1），可用于治疗病毒性感染疾病（如艾滋病毒感染）、风湿病和癌症转移等疾病。其中，A1和A2代表氢原子或可替换的单环或多环杂芳香环，W代表可替换的苯环或以下化学式（10）或（11）所代表的任何基团： 其中，X代表O、CH2、C(═O)、NR11或CHR35，D代表以下化学式（6）所代表的基团： 其中，Q代表单键、NR12或以下化学式（13）所代表的基团，Y代表以下化学式（7）所代表的基团： 其中，z代表可替换的单环或多环芳香环，B代表—NR25R26，R1到R26代表氢原子、烷基、烯基或炔基。
• Compound containing basic group and use thereof
  申请人：Ono Pharmaceutical Co., Ltd.

  公开号：US07951816B2

  公开（公告）日：2011-05-31

  The present invention relates to a compound represented by formula (I-0): wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous disease (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

  本发明涉及一种由式（I-0）表示的化合物：其中式中的符号与本说明书中描述的含义相同，其盐、N-氧化物或其溶剂合物或其前药，以及其医疗用途。本发明的化合物具有对CXCR4的拮抗活性，因此可用作CXCR4介导疾病的预防和/或治疗剂，例如炎症和免疫疾病（例如类风湿性关节炎、关节炎、视网膜病、肺纤维化、移植器官排斥等）、过敏性疾病、感染病（例如人类免疫缺陷病毒感染、获得性免疫缺陷综合征等）、精神神经疾病、脑部疾病、心血管疾病、代谢性疾病和癌症等，或作为再生治疗剂。