[5-(9-Cyano-4,6-dimethyl-5-oxobenzo[c][2,7]naphthyridin-8-yl)oxy-4-methylpentan-2-yl]carbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [5-(9-Cyano-4,6-dimethyl-5-oxobenzo[c][2,7]naphthyridin-8-yl)oxy-4-methylpentan-2-yl]carbamic acid
• 英文别名: [5-(9-cyano-4,6-dimethyl-5-oxobenzo[c][2,7]naphthyridin-8-yl)oxy-4-methylpentan-2-yl]carbamic acid
• 化学式: C₂₂H₂₄N₄O₄
• 分子量: 408.4
• InChiKey: LAADMZFPWAXLPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] ARYL LACTAM KINASE INHIBITORS<br/>[FR] INHIBITEURS D'ARYL-LACTAME KINASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015116060A1

  公开（公告）日：2015-08-06

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本公开涉及一般可抑制AAK1（适配器相关激酶1）的化合物，包括这种化合物的组合物，以及抑制AAK1的方法。
• ARYL LACTAM KINASE INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2880032A1

  公开（公告）日：2015-06-10
• [EN] ARYL LACTAM KINASE INHIBITORS<br/>[FR] INHIBITEURS D'ARYL LACTAME KINASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014022167A1

  公开（公告）日：2014-02-06

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.