[7-(4-bromobutoxy)-2-oxo-3,4-dihydro-1H-quinolin-4-yl]methylcarbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [7-(4-bromobutoxy)-2-oxo-3,4-dihydro-1H-quinolin-4-yl]methylcarbamic acid
• 化学式: C₁₅H₁₉BrN₂O₄
• 分子量: 371.23
• InChiKey: XUWDKOKYYBGRED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] HAPTENS OF ARIPIPRAZOLE AND THEIR USE IN IMMUNOASSAYS<br/>[FR] HAPTÈNES D'ARIPIPRAZOLE ET LEUR UTILISATION DANS DES DOSAGES IMMUNOLOGIQUES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014031584A1

  公开（公告）日：2014-02-27

  The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

  该发明涉及到Formula I的化合物，其中R1、R2和R3在说明书中有定义，用于合成源自阿立哌唑的新型结合物和免疫原。该发明还涉及到阿立哌唑半抗原和蛋白质的结合物。
• HAPTENS OF ARIPIPRAZOLE
  申请人：Ortho-Clinical Diagnostics, Inc.

  公开号：US20140163206A1

  公开（公告）日：2014-06-12

  The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

  本发明涉及公式I的化合物，其中R1、R2和R3在规范中定义，用于合成源自ariipiprazole的新型结合物和免疫原。本发明还涉及ariipiprazole半抗原和蛋白质的结合物。
• Haptens of aripiprazole
  申请人：Janssen Pharmaceutica NV

  公开号：US10166296B2

  公开（公告）日：2019-01-01

  The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

  本发明涉及式 I 化合物，其中 R1、R2 和 R3 在说明书中定义，可用于合成由阿立哌唑衍生的新型共轭物和免疫原。本发明还涉及阿立哌唑合剂与蛋白质的共轭物。
• Antibodies to aripiprazole haptens and use thereof
  申请人：Janssen Pharmaceutica NV

  公开号：US10379105B2

  公开（公告）日：2019-08-13

  Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

  本发明公开了一种与阿立哌唑结合的抗体，可用于检测样品中的阿立哌唑，如竞争性免疫分析法。该抗体可用于横向流动检测装置，进行阿立哌唑的床旁检测，包括在单个横向流动检测装置中对阿立哌唑、奥氮平、喹硫平和利培酮进行多重检测。
• HAPTENS OF ARIPIPRAZOLE AND THEIR USE IN IMMUNOASSAYS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2888234A1

  公开（公告）日：2015-07-01