(2E,8E,10E)-N,N-diethyldodeca-2,8,10-trienamide | 550346-99-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,8E,10E)-N,N-diethyldodeca-2,8,10-trienamide
• CAS: 550346-99-1
• 化学式: C₁₆H₂₇NO
• 分子量: 249.396
• InChiKey: FIXVDFCEKLUDIJ-VFOPAHIMSA-N

物化性质

• 沸点：
  394.7±21.0 °C(Predicted)
• 密度：
  0.897±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2E,8E,10E)-N,N-diethyldodeca-2,8,10-trienamide 以 甲苯 为溶剂， 反应 144.0h， 生成 、
  参考文献：
  名称：

  Synthesis of (±)-solanapyrones A and B

  摘要：

  In this paper we report the development of a stereoselective IMDA approach to the phytotoxic polyketides (+/-)-solanapyrones A and B. The stereoselectivity of the key IMDA cycloaddition was optimized by investigating a range of 2,8,10-dodecatrienoic acid derivatives. This established that use of the Weinreb amide led to the desired exo-selectivity and also facilitated construction of the pyrone moiety. A novel approach to the installation of the C-3 formyl group in solanapyrone A is also described. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00288-0
• 作为产物：
  描述：

  ethyl (2E,8E,10E)-dodeca-2,8,10-trienoate 在 N-甲基吗啉 、 lithium hydroxide 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 (2E,8E,10E)-N,N-diethyldodeca-2,8,10-trienamide
  参考文献：
  名称：

  Synthesis of (±)-solanapyrones A and B

  摘要：

  In this paper we report the development of a stereoselective IMDA approach to the phytotoxic polyketides (+/-)-solanapyrones A and B. The stereoselectivity of the key IMDA cycloaddition was optimized by investigating a range of 2,8,10-dodecatrienoic acid derivatives. This established that use of the Weinreb amide led to the desired exo-selectivity and also facilitated construction of the pyrone moiety. A novel approach to the installation of the C-3 formyl group in solanapyrone A is also described. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00288-0

文献信息

• Synthesis of (±)-solanapyrones A and B
  作者：Barry Lygo、Mohamed Bhatia、Jason W.B. Cooke、David J. Hirst

  DOI：10.1016/s0040-4039(03)00288-0

  日期：2003.3

  In this paper we report the development of a stereoselective IMDA approach to the phytotoxic polyketides (+/-)-solanapyrones A and B. The stereoselectivity of the key IMDA cycloaddition was optimized by investigating a range of 2,8,10-dodecatrienoic acid derivatives. This established that use of the Weinreb amide led to the desired exo-selectivity and also facilitated construction of the pyrone moiety. A novel approach to the installation of the C-3 formyl group in solanapyrone A is also described. (C) 2003 Elsevier Science Ltd. All rights reserved.