6-[1-[3-(4-chlorophenoxy)-2-hydroxypropyl]piperidin-4-yl]oxy-3,4-dihydro-1H-quinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[1-[3-(4-chlorophenoxy)-2-hydroxypropyl]piperidin-4-yl]oxy-3,4-dihydro-1H-quinolin-2-one
• 化学式: C₂₃H₂₇ClN₂O₄
• 分子量: 430.931
• InChiKey: LGOQMYAABWPPKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  71
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：NEUROP INC

  公开号：WO2013170072A2

  公开（公告）日：2013-11-14

  In one aspect, the invention relates to NMDA receptor modulators, derivatives thereof, and related compounds, which are useful as inhibitors of the NMDA receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating or preventing neurological and psychiatric disorders associated with NMDA receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.