2-[2-[2-[2-[[4-[(4-amino-2-butylimidazo[4,5-c]quinolin-1-yl)methyl]phenyl]methylamino]-2-oxoethoxy]ethoxy]ethoxy]-N-prop-2-ynylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[2-[2-[2-[[4-[(4-amino-2-butylimidazo[4,5-c]quinolin-1-yl)methyl]phenyl]methylamino]-2-oxoethoxy]ethoxy]ethoxy]-N-prop-2-ynylacetamide
• 化学式: C₃₃H₄₀N₆O₅
• 分子量: 600.7
• InChiKey: UNOXNODBWXAXGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  44
• 可旋转键数：
  18
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] TLR-AGONIST-CONJUGATED ANTIBODY RECRUITING MOLECULES (TLR_ARMS)<br/>[FR] MOLÉCULES DE RECRUTEMENT D'ANTICORPS CONJUGUÉS À UN AGONISTE DE TLR)
  申请人：UNIV YALE

  公开号：WO2013166110A1

  公开（公告）日：2013-11-07

  The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.

  本发明涉及嵌合化学化合物，用于招募抗体到癌细胞，特别是前列腺癌细胞或转移的前列腺癌细胞。根据本发明的化合物包括一个与细胞结合末端（CBT）和通过连接物和多功能连接组或分子共价结合的抗体结合末端（ABT）基团和Toll样受体激动剂（TLR）。
• TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)
  申请人：YALE UNIVERSITY

  公开号：US10016412B2

  公开（公告）日：2018-07-10

  The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.

  本发明涉及用于将抗体募集到癌细胞，特别是前列腺癌细胞或转移的前列腺癌细胞的嵌合化学化合物。根据本发明的化合物包括抗体结合末端（ABT）分子，通过连接体和多功能连接基团或分子与细胞结合末端（CBT）和Toll样受体激动剂（TLR）共价键合。
• TLR-AGONIST-CONJUGATED ANTIBODY RECRUITING MOLECULES (TLR-ARMS)
  申请人：YALE UNIVERSITY

  公开号：US20150110742A1

  公开（公告）日：2015-04-23

  The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
• TLR-AGONIST-CONJUGATED ANTIBODY RECRUITING MOLECULES (TLR-ARMs)
  申请人：YALE UNIVERSITY

  公开号：US20170087148A1

  公开（公告）日：2017-03-30

  The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
• US9556167B2
  申请人：——

  公开号：US9556167B2

  公开（公告）日：2017-01-31